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Live attenuated versus inactivated influenza vaccine in infants and young children.
TLDR
An evaluation of the risks and benefits indicates that live attenuated vaccine should be a highly effective, safe vaccine for children 12 to 59 months of age who do not have a history of asthma or wheezing. Expand
Efficacy results of a trial of a herpes simplex vaccine.
TLDR
In a study population that was representative of the general population of HSV-1- and HSv-2-seronegative women, the investigational vaccine was effective in preventing HSV -1 genital disease and infection but not in preventingHSV-2 disease or infection. Expand
Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response
TLDR
Results provide evidence for immunosenescence in DCs; notably, defects in cytokine production were strongly associated with poor response to influenza immunization, a functional consequence of impaired TLR function in the aging innate immune response. Expand
The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children.
TLDR
A live attenuated, cold-adapted, trivalent influenzavirus vaccine was safe, immunogenic, and effective against influenza A(H3N2) and B in healthy children. Expand
Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children.
TLDR
Prime/boost combinations of LAIV and TIV in young children were safe and induced similar protective antibodies, including T cells specific for highly conserved influenza peptides relevant for broadly protective heterosubtypic immunity. Expand
Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection.
TLDR
Analysis of reassortant viruses generated with a resistant clinical isolate and the susceptible influenza A/Singapore/57 (H2N2) virus indicated that RNA segment 7 coding for matrix and M2 proteins conferred the resistant phenotype. Expand
Emergence and apparent transmission of rimantadine-resistant influenza A virus in families.
TLDR
It is concluded that when index patients are treated concurrently, rimantadine is ineffective in protecting household members from influenza A infection and rapid selection and apparent transmission of drug-resistant influenza A viruses can occur. Expand
Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis.
TLDR
PEP of household contacts of those with influenza reduces the secondary spread of influenza in families when the initial household case is treated, and provides a protective efficacy for households against proven influenza. Expand
Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women.
TLDR
HSV-1 is now more common than HSV-2 as a cause of oral and genital mucosal infections in young women, but there are important age and race differences. Expand
Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. The National Institute
TLDR
There is a qualitative, or large quantitative, difference in the neutralizing antibody response induced by envelope subunit vaccination and natural HIV-1 infection, which is more susceptible to neutralization than are primary isolates cultured in human peripheral blood mononuclear cells. Expand
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