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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality
IntroductionThere is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and
Acute renal failure in critically ill patients: a multinational, multicenter study.
In this multinational study, the period prevalence of ARF requiring RRT in the ICU was between 5% and 6% and was associated with a high hospital mortality rate.
Intensive versus conventional glucose control in critically ill patients.
In this large, international, randomized trial, it was found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did a target of 81 to 108 mg perDeciliter.
Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial
Mortality among critically ill patients with acute renal failure was high, but increase in the rate of ultrafiltration improved survival significantly, and it is recommended thatUltrafiltration should be prescribed according to patient's bodyweight and should reach at least 35 mL h(-1) kg(-1).
Goal-directed resuscitation for patients with early septic shock.
In critically ill patients presenting to the emergency department with early septic shock, EGDT did not reduce all-cause mortality at 90 days and there was no significant difference in survival time, in-hospital mortality, duration of organ support, or length of hospital stay.
Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study
This is the first multinational cross-sectional study on the epidemiology of AKI in ICu patients using the complete KDIGO criteria and found that AKI occurred in more than half of ICU patients.
Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial
The MET system greatly increases emergency team calling, but does not substantially affect the incidence of cardiac arrest, unplanned ICU admissions, or unexpected death.
Findings of the First Consensus Conference on Medical Emergency Teams*
Hospitals should implement an RRS, which consists of four elements: an afferent, “crisis detection” and “response triggering” mechanism; an efferent, predetermined rapid response team; a governance/administrative structure to supply and organize resources; and a mechanism to evaluate crisis antecedents and promote hospital process improvement to prevent future events.
A comparison of albumin and saline for fluid resuscitation in the intensive care unit.
In patients in the ICU, use of either 4 percent albumin or normal saline for fluid resuscitation results in similar outcomes at 28 days, with no significant differences between the groups.