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Expression of Toll-like receptor 9 increases with progression of cervical neoplasia in Tunisian women--a comparative analysis of condyloma, cervical intraepithelial neoplasia and invasive carcinoma.
The results suggest that TLR9 may play a role in progression of cervical neoplasia in Tunisian patients and could represent a useful biomarker for malignant transformation of cervical squamous cells.
Insecticidal effects of Buthus occitanus tunetanus BotIT6 toxin expressed in Escherichia coli and baculovirus/insect cells.
A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site.
The role of Toll-like receptor 9 in gynecologic cancer.
Molecular cloning and nucleotide sequence analysis of encoded anti-insect toxin BotIT2 from the scorpion Buthus occitanus tunetanus venom.
- R. Bel Haj Rhouma, H. Dkhil, K. Benkhadir, L. Borchani, M. El Ayeb, H. Karoui
- Biology, ChemistryArchives de l'Institut Pasteur de Tunis
Using amino acid sequences of BotIT2 and RACE-PCR amplification technique, the nucleotide sequence from the venom glands of the scorpion Buthus occitanus tunetanus was isolated, identified and sequenced as a precursor of an insect toxin of 60 amino acid residues.
[In vivo and in vitro protection against lethal activity of Buthus occitanus tunetanus venom with a recombinant protein].
- K. Benkhadir, T. Mejri, R. Bel Haj Rhouma, M. El Ayeb, H. Karoui
- BiologyArchives de l'Institut Pasteur de Tunis
The use of recombinant scorpion toxin in the form of fusion protein as antigen for mice immunisation produces protective antisera against lethal activity of the venom from Tunisian scorpion Buthus occitanus tunetanus.
Distribution of human papillomavirus in precancerous and cancerous cervical neoplasia in Tunisian women
Investigating the HPV genotypes distribution in cervical neoplasia in Tunisian women in order to predict the impact of using current HPV vaccines on cancer prevention can give useful information for vaccine implementation by helping the health policymakers to choose the most appropriate vaccine type in Tunisia.