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Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog.
The data suggest that a P-glycoprotein may play a role in ivermectin resistance in the sheep nematode parasite Haemonchus contortus and the multidrug resistance reversing agent, verapamil, increased the efficacy of iverMectin and moxidectin against a moxodectin-selected strain of this nematodes in jirds. Expand
Population biology of parasitic nematodes: applications of genetic markers.
The chapter describes levels of heterozygosity revealed by allozymes and patterns of variation in a variety of different sequence types that are distributed in parasite populations, and the ways these patterns can be used to ask questions about the various aspects of nematode biology and epidemiology. Expand
Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus.
Findings suggest that P-glycoprotein may be involved in resistance to both ivermectin and moxidectin in H. contortus. Expand
Study of the nematode putative GABA type‐A receptor subunits: evidence for modulation by ivermectin
It is demonstrated that the coexpressed HG1 and GAB‐1 receptors are GABA‐responsive, and evidence for the possible involvement of GABA receptors in the mechanism of ivermectin resistance is provided. Expand
Anthelmintic resistance: markers for resistance, or susceptibility?
SUMMARY The Consortium for Anthelmintic Resistance and Susceptibility (CARS) brings together researchers worldwide, with a focus of advancing knowledge of resistance and providing information onExpand
The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery
The H. contortus genome and transcriptome provide an essential platform for postgenomic research in this and other important strongylid parasites and provide the most comprehensive understanding yet of the action of several important anthelmintics. Expand
Haemonchus contortus: selection at a glutamate-gated chloride channel gene in ivermectin- and moxidectin-selected strains.
A correlation between changes in allele frequencies of the putative alpha-subunit gene and resistance to ivermectin and moxidectin is suggested. Expand
Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions
Graphical abstract
P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles.
Genetic evidence of selection at a P-glycoprotein locus during selection for benzimidzole resistance in H. contortus is presented and it is found that one allele in particular increased substantially. Expand
Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus.
Allelic variation at two beta-tubulin genes in Haemonchus contortus is identified using restriction map analysis of individual adults and confirms that changes in allele frequency, rather than novel genetic rearrangements induced by exposure to the drug, explain the changes associated with benzimidazole resistance. Expand