• Publications
  • Influence
Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence.
Systematic consideration of scientific support is a critical element in developing and, ultimately, using adverse outcome pathways (AOPs) for various regulatory applications. Though weight ofExpand
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Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective.
Advances in both sensitivity and specificity of analytical chemistry have made it possible to quantify substances in human biological specimens, such as blood, urine, and breast milk, in specimenExpand
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Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes.
TLDR
An adverse outcome pathway (AOP) describes the causal linkage between initial molecular events and an adverse outcome at individual or population levels. Expand
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Validation of an in vivo developmental toxicity screen in the mouse.
A test system for identifying toxicity, including potential teratogenicity has been developed that is based on growth and viability of embryonic, fetal, and postnatal mice (J Toxicol Environ HealthExpand
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Building scientific confidence in the development and evaluation of read-across.
Read-across is an alternative approach exploited to address information requirements for risk assessment and for regulatory programmes such as the European Union's REACH regulation. WhilstExpand
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Toxicity testing in the 21st century: a view from the chemical industry.
  • J. Bus, R. Becker
  • Medicine, Engineering
  • Toxicological sciences : an official journal of…
  • 1 December 2009
The rapid onset of the science and experimental tools of molecular biology and genomics has presented the toxicology community with an unprecedented opportunity to reexamine, and potentiallyExpand
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Relevance weighting of tier 1 endocrine screening endpoints by rank order.
TLDR
Weight of evidence (WoE) approaches are recommended for interpreting various toxicological data, but few systematic and transparent procedures exist. Expand
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A survey of frameworks for best practices in weight-of-evidence analyses
Abstract The National Academy of Sciences (NAS) Review of the Environmental Protection Agency’s Draft IRIS Assessment of Formaldehyde proposed a “roadmap” for reform and improvement of the Agency’sExpand
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Evaluation of EPA's Tier 1 Endocrine Screening Battery and recommendations for improving the interpretation of screening results.
TLDR
EPA's Endocrine Disruptor Screening Program (EDSP) was implemented in 2009-2010 with the issuance of test orders requiring manufacturers and registrants of 58 pesticide active ingredients and nine pesticide inert/high production volume chemicals to evaluate the potential of these chemicals to interact with the estrogen, androgen and thyroid hormone systems. Expand
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Quantitative weight of evidence to assess confidence in potential modes of action
&NA; The evolved World Health Organization/International Programme on Chemical Safety mode of action (MOA) framework provides a structure for evaluating evidence in pathways of causally linked keyExpand
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