• Publications
  • Influence
The global burden of asthma: executive summary of the GINA Dissemination Committee Report
TLDR
This report provides a wealth of information that will be an invaluable source of information for those who wish to explore available data on the burden of asthma by region and will be extremely useful to develop background materials for World Asthma Day activities in 2004 and well into the future.
Benefits of omalizumab as add‐on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
TLDR
The effect of omalizumab on clinically significant asthma exacerbations (requiring systemic corticosteroids) is determined in the first omalIZumab study to exclusively enrol patients from this difficult‐to‐treat patient population.
Epidemiology and costs of chronic obstructive pulmonary disease
TLDR
COPD is under-diagnosed not only in its early stages, but even when lung function is severely impaired, and the message that COPD is both preventable and treatable has yet to be fully understood by most healthcare providers.
Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial.
TLDR
Among patients receiving crystalloid fluid therapy in the ICU, use of a buffered crystalloid compared with saline did not reduce the risk of AKI and main secondary outcomes were incidence of RRT use and in-hospital mortality.
After asthma: redefining airways diseases
Effects of cannabis on pulmonary structure, function and symptoms
TLDR
Smoking cannabis was associated with a dose-related impairment of large airways function resulting in airflow obstruction and hyperinflation and the 1:2.5–5 dose equivalence between cannabis joints and tobacco cigarettes for adverse effects on lung function is of major public health significance.
Treatable traits: toward precision medicine of chronic airway diseases
TLDR
This Perspective proposes a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular, and a discussion of the concept of “treatable traits” as a way towards precision medicine of chronicAirway diseases.
Proportional classifications of COPD phenotypes
TLDR
This study provides proportional classifications of the phenotypic subgroups of COPD which can be used as the basis for further research into the pathogenesis and treatment of this heterogeneous disorder.
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