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Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands.
We investigated how dopamine (DA) systems contribute to cognitive performance in the domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic medication in patientsExpand
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The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort.
Cognitive abnormalities are common in Parkinson's disease, with important social and economic implications. Factors influencing their evolution remain unclear but are crucial to the development ofExpand
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Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease
Cognitive impairment in patients with Parkinson's disease is gaining increased clinical significance owing to the relative success of therapeutic approaches to the motor symptoms of this disorder.Expand
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Evolution of cognitive dysfunction in an incident Parkinson's disease cohort.
We have previously performed detailed clinical and neuropsychological assessments in a community-based cohort of patients with newly diagnosed parkinsonism, and through analysis of a subcohort withExpand
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RNA velocity of single cells
RNA velocity, estimated in single cells by comparison of spliced and unspliced mRNA, is a good indicator of transcriptome dynamics and will provide a useful tool for analysis of developmental lineage. Expand
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Disintegration of the Sleep-Wake Cycle and Circadian Timing in Huntington's Disease
Sleep disturbances in neurological disorders have a devastating impact on patient and carer alike. However, their pathological origin is unknown. Here we show that patients with Huntington's diseaseExpand
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Mechanisms of cognitive set flexibility in Parkinson's disease.
Previous research on cognitive set shifting in patients with Parkinson's disease has often been confounded by concept formation, rule learning, working memory and/or general slowing of cognitiveExpand
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A pathophysiological model of freezing of gait in Parkinson's disease.
Freezing of gait (FOG) is a common phenomenon in Parkinson's disease (PD) affecting over half of those in the advanced stages of the disease and often does not respond to standard drug therapies.Expand
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L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease
Evidence indicates that dopaminergic medication in Parkinson's disease may impair certain aspects of cognitive function, such as reversal learning. We used functional magnetic resonance imaging inExpand
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Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET.
This study examined the effects of L-dopa medication in patients with Parkinson's disease on cortical and subcortical blood flow changes during two tasks known to involve frontostriatal circuitry.Expand
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