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Nomenclature of Voltage-Gated Sodium Channels
Voltage-gated Ca2+ channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression.Expand
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Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.
The principal voltage-sensitive sodium channel from human heart has been cloned, sequenced, and functionally expressed. The cDNA, designated hH1, encodes a 2016-amino acid protein that is homologousExpand
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Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscle
The alpha subunit of a voltage-sensitive sodium channel characteristic of denervated rat skeletal muscle was cloned and characterized. The cDNA encodes a 2018 amino acid protein (SkM2) that isExpand
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Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro.
  • N. Yang, S. Ji, +4 authors A. George
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 20 December 1994
Mutations in the skeletal muscle voltage-gated Na+ channel alpha-subunit have been found in patients with two distinct hereditary disorders of sarcolemmal excitation: hyperkalemic periodic paralysisExpand
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Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita
The periodic paralyses are a group of autosomal dominant muscle diseases sharing a common feature of episodic paralysis. In one form, paramyotonia congenita (PC), the paralysis usually occurs withExpand
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Characteristics of the chloride conductance in muscle fibers of the rat diaphragm
In muscle fibers from the rat diaphragm, 85% of the resting membrane ion conductance is attributable to Cl-. At 37 degree C and pH 7.0, GCl averages 2.11 mmho/cm2 while residual conductance largelyExpand
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Characteristics of saxitoxin binding to the sodium channel of sarcolemma isolated from rat skeletal muscle.
1. The characteristics of saxitoxin (STX) binding to the mammalian Na channel have been studied in purified sarcolemma isolated from rat skeletal muscle. 2. STX binds specifically to isolatedExpand
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Modulation of sodium-channel mRNA levels in rat skeletal muscle.
Action potentials in many types of excitable cells result from changes in permeability to Na ions. Although these permeability changes in nerve and muscle are mediated by voltage-gated Na channelsExpand
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TTX-sensitive and TTX-insensitive sodium channel mRNA transcripts are independently regulated in adult skeletal muscle after denervation
The expression of mRNA encoding the TTX-sensitive (SkM1) and TTX-insensitive (SkM2) voltage-dependent sodium channels in adult skeletal muscle is independently regulated. In normal skeletal muscle,Expand
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Loss of electrical excitability in an animal model of acute quadriplegic myopathy
In rats treated with high‐dose corticosteroids, skeletal muscle that is denervated in vivo (steroid‐denervated [S‐D]) develops electrical inexcitability similar to that seen in patients with acuteExpand
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