• Publications
  • Influence
In-vivo measurement of activated microglia in dementia
In-vivo detection of increased [11C](R)-PK11195 binding in Alzheimer-type dementia, including mild and early forms, suggests that microglial activation is an early event in the pathogenesis of the disease. Expand
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
This study identifies by microautoradiography activated microglia/macrophages as the main cell type expressing the peripheral benzodiazepine binding site (PBBS) at sites of active CNS pathology.Expand
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
In vivo findings confirm that widespread microglial activation is associated with the pathological process in PD and suggest that microglia are activated early in the disease process, and levels then remain relatively static, possibly driving the disease via cytokine release. Expand
Visualising microglial activation in vivo
  • R. Banati
  • Biology, Medicine
  • Glia
  • 1 November 2002
These data suggest that the injured brain is less static than commonly thought and shows subtle glial responses even in macroanatomically stable appearing regions, which implies that glial activation is not solely a sign of tissue destruction, but possibly of disease‐induced adaptation or plasticity as well. Expand
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study
The findings indicate that cerebral microglial activation can be detected in vivo during the evolution of ALS, and support the previous observations that cerebral pathology is widespread, and argue for the development of therapeutic strategies aimed at inflammatory pathways. Expand
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research
A summary of factors that influence transmucosal nasal drug delivery, deposition, and their impact on bioavailability is provided, including variations in anatomy and resultant airflow dynamic, vascularisation, status of blood vessels, mode of spray application, gallenic formulation, and amount and method of administration. Expand
Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease
It remains to be determined to what extent the activation of glial cells reflects progressive nigral pathology, and whether those factors which are classically associated with prominent apoptotic neuronal cell death in vivo, such as neurotrophic factor deprivation, are prime causes of nigral neuronal loss in PD. Expand
The functional anatomy of visual-tactile integration in man: a study using positron emission tomography
The pattern of brain activation is congruent with areas of heteromodal and supramodal cortex and indicates that activation of multimodal areas is required to solve the crossmodal problem. Expand
Cytotoxicity of microglia
Interference with the microglial activation or the productions of cytotoxic metabolites by microglia may offer new therapeutic opportunities for the prevention of neuronal cell death in CNS disease. Expand
Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease
A detailed summary on their cellular response is given, the different classes of molecules expressed and their attribution to the blood derived or brain-resident macrophages are described and how these molecules contribute to the neuropathology are discussed. Expand