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Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophagesExpand
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  • Open Access
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
Human plasmacytoid dendritic cells (DC) (PDC, CD123+) and myeloid DC (MDC, CD11c+) may be able to discriminate between distinct classes of microbial molecules based on a different pattern ofExpand
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The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface.
The airway surface is an important host defense against pulmonary infection. Secretion of proteins with antimicrobial activity from epithelial cells onto the airway surface represents an importantExpand
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  • Open Access
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.
Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide LL-37/hCAP-18 isExpand
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  • Open Access
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.
Previous studies have implicated the novel peptide antibiotic human beta-defensin 1 (hBD-1) in the pathogenesis of cystic fibrosis. We describe in this report the isolation and characterization ofExpand
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Epithelial antimicrobial peptides in host defense against infection
  • R. Bals
  • Biology, Medicine
  • Respiratory research
  • 20 October 2000
One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs.Expand
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Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity
β‐Defensins are antibiotic peptides involved in host defense at the epithelial surface. Three human β‐defensins (hBDs)‐‐hBD‐1, hBD‐2, and hBD‐3‐‐have been identified so far. We have characterized aExpand
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Cathelicidins - a family of multifunctional antimicrobial peptides
Abstract. One component of host defence at mucosal surfaces are epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conservedExpand
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[Pathogenesis of chronic obstructive pulmonary disease].
It is currently believed that the most important factor in the pathogenesis of chronic obstructive pulmonary disease (COPD) is inflammation of the small airways caused by inhaled particles and gases.Expand
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Innate immunity in the lung: how epithelial cells fight against respiratory pathogens
The human lung is exposed to a large number of airborne pathogens as a result of the daily inhalation of 10,000 litres of air. The observation that respiratory infections are nevertheless rare isExpand
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  • Open Access