R. Balk

Publications360
h-index56
Citations32,557
Highly Influential Citations797
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Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of…
TLDR
Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic parameters by which a patient may be categorized, and the use of severity scoring methods when dealing with septic patients was recommended as an adjunctive tool to assess mortality. Expand
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of…
An American College ofChest Physicians/Society ofCritical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of de6nitions that could be… Expand
Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial
Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome
TLDR
Study of lipopolysaccharide and cytokine levels in 97 patients with the sepsis syndrome found a positive correlation between high levels of plasma TNF- and mortality, and implicate T NF- as an important mediator in sepsi. Expand
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
TLDR
It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock. Expand
Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults.
TLDR
The incidence of community-acquired pneumonia requiring hospitalization was highest among the oldest adults and despite current diagnostic tests, no pathogen was detected in the majority of patients. Expand
Sepsis: a new hypothesis for pathogenesis of the disease process.
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group.
TLDR
In patients with septic shock, treatment with the TNFR:Fc fusion protein does not reduce mortality, and higher doses appear to be associated with increased mortality. Expand
Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestations.
  • R. Balk
  • Medicine
  • Critical care clinics
  • 1 April 2000
TLDR
It is hoped that adoption of uniform definitions will aid in research and in effective communication concerning sepsis and its adverse sequelae. Expand
Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial
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