Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of…
- R. Bone, R. Balk, W. Sibbald
- MedicineChest
- 1 June 1992
Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic parameters by which a patient may be categorized, and the use of severity scoring methods when dealing with septic patients was recommended as an adjunctive tool to assess mortality.
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of…
- R. Bone, R. Balk, W. Sibbald
- MedicineChest
- 2009
An American College ofChest Physicians/Society ofCritical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of de6nitions that could be…
Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial
- R. Balk
- Medicine
- 2010
Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome
Study of lipopolysaccharide and cytokine levels in 97 patients with the sepsis syndrome found a positive correlation between high levels of plasma TNF- and mortality, and implicate T NF- as an important mediator in sepsi.
Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults.
- Seemalata Jain, W. Self, L. Finelli
- MedicineNew England Journal of Medicine
- 29 July 2015
The incidence of community-acquired pneumonia requiring hospitalization was highest among the oldest adults and despite current diagnostic tests, no pathogen was detected in the majority of patients.
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
- R. Bone, C. Fisher, T. Clemmer, G. Slotman, C. Metz, R. Balk
- MedicineNew England Journal of Medicine
- 10 September 1987
It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock.
Sepsis: a new hypothesis for pathogenesis of the disease process.
- R. Bone, C. Grodzin, R. Balk
- MedicineChest
- 1 July 1997
Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European…
- D. Annane, S. Pastores, G. Van den Berghe
- Medicine, BiologyIntensive Care Medicine
- 23 February 2018
Evidence-based recommendations for the use of corticosteroids in critically ill patients with sepsis and septic shock, acute respiratory distress syndrome, and major trauma have been developed by a multispecialty task force.
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group.
- C. Fisher, J. Agosti, E. Benjamin
- MedicineNew England Journal of Medicine
- 27 June 1996
In patients with septic shock, treatment with the TNFR:Fc fusion protein does not reduce mortality, and higher doses appear to be associated with increased mortality.
Sepsis syndrome: a valid clinical entity
- R. Bone, C. Fisher, T. Clemmer, G. Slotman, C. Metz, R. Balk
- Medicine
- 1 May 1989
The sepsis syndrome represents a systemic response to infection and is defined as hypothermia or hyperthermia, tachycardia, tachypnea, clinical evidence of an infection site and with at least one end-organ demonstrating inadequate perfusion or dysfunction expressed as poor or altered cerebral function.
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