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The CRAPome: a Contaminant Repository for Affinity Purification Mass Spectrometry Data
Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for the identification of protein-protein interactions. However, for any given protein of interest, determiningExpand
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Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions
Phosphoprotein recognition directs kinase-phosphatase interactions at multiple levels in the mammalian Hippo pathway. Switching Partners in the Hippo Pathway The Hippo kinase cascade, named for theExpand
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Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins
Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanismsExpand
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A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle*S
Lysosomes are endocytic subcellular compartments that contribute to the degradation and recycling of cellular material. Using highly purified rat liver tritosomes (Triton WR1339-filled lysosomes) andExpand
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The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes.
Lysosomes are late-endocytic organelles which primarily contribute to degradation and recycling of cellular material. From a previous proteomics study of purified rat liver lysosomal membranes weExpand
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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane*
Alzheimer's disease (AD) is caused by the cerebral deposition of β-amyloid (Aβ), a 38–43-amino acid peptide derived by proteolytic cleavage of the amyloid precursor protein (APP). Initial studiesExpand
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Membrane‐associated estrogen receptor and caveolin‐1 are present in central nervous system myelin and oligodendrocyte plasma membranes
The estrogen receptor (ER) is a member of a superfamily of ligand‐regulated transcription factors that were thought to localize primarily to the nucleus; however, a membrane‐associated ER that canExpand
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Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C).
Mucopolysaccharidosis IIIC (MPS IIIC), or Sanfilippo C, represents the only MPS disorder in which the responsible gene has not been identified; however, the gene has been localized to theExpand
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Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor
Significance Intracellular signaling during complex cell–cell interactions, such as between immune cells, provides essential cues leading to cell responses. Global characterization of these signalingExpand
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Salmonella exploits Arl8B‐directed kinesin activity to promote endosome tubulation and cell‐to‐cell transfer
The facultative intracellular pathogen Salmonella enterica serovar Typhimurium establishes a replicative niche, the Salmonella‐containing vacuole (SCV), in host cells. Here we demonstrate that theseExpand
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