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The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?
TLDR
Evidence exists that genetic polymorphisms, drug‐drug interactions, drug-disease interactions and other factors are important determinants of the variability in the therapeutic response to carboxylesterase‐substrate drugs. Expand
Effects of Alcohol on Human Carboxylesterase Drug Metabolism
TLDR
The results suggest that alcohol’s inhibition of CES1 could potentially result in clinically significant drug interactions with other CES1-substrate drugs, but it is unlikely to significantly affect CES2- Substrate drug hydrolysis. Expand
Cocaethylene metabolism and interaction with cocaine and ethanol: role of carboxylesterases.
TLDR
Following administration of cocaethylene alone, benzoylecgonine achieved similar plasma concentrations as those attained following cocaine alone, which indicates that benzoyleCgonine is a major metabolite of coc aethylene. Expand
Identification of Carboxylesterase-Dependent Dabigatran Etexilate Hydrolysis
TLDR
Results suggest that after oral administration of DabE to humans, DABE is hydrolyzed by intestinal CES2 to the intermediate M2 metabolite followed by hydrolysis of M2 to DAB in the liver by CES1, and carboxylesterase-mediated hydrolytic process was not inhibited by alcohol. Expand
The Importance of Research and Scholarly Activity in Pharmacy Training
TLDR
The importance of providing research opportunities for students and residents is highlighted, the potential barriers to these activities are described, and recommendations on how to increase the instruction and mentoring of trainees to generate and use research are provided. Expand
Discontinuation/Interruption of Warfarin Therapy in Patients with Nonvalvular Atrial Fibrillation.
TLDR
A retrospective cohort study on the rates and predictors of warfarin discontinuation/interruption in patients with nonvalvular AF in the usual clinical practice settings in the United States to determine demographic, clinical, and health care-related factors associated with discontinuation and interruption. Expand
The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions
TLDR
The coadministration of ethanol and cocaine resulted in a 23% decrease in the clearance of intravenous cocaine and a 300% increase in the bioavailability of oral cocaine, inferring from these results that ethanol could inhibit the hydrolysis of other drug compounds subject to Hydrolysis by carboxylesterases. Expand
Preparing Clinical Pharmacy Scientists for Careers in Clinical/Translational Research: Can We Meet the Challenge?
TLDR
The potential impact of changes in the economic, professional, political, and research environments on opportunities for pharmacists in clinical/translational research are discussed as are strategies for ACCP, colleges of pharmacy, and the profession to increase the number and impact of clinical pharmacy scientists. Expand
Physiologically Based Pharmacokinetic Modeling of Impaired Carboxylesterase-1 Activity: Effects on Oseltamivir Disposition
TLDR
The PBPK model of impaired CES1 activity correctly predicts observed human data and can be extended to predict the effects of drug interactions and other factors affecting the pharmacokinetics of other CES1 substrate drugs. Expand
Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects
TLDR
Inspiration of caffeine as a fine powder using the AeroShot device produces a similar caffeine profile and effects compared to administration of an oral solution (energy drink). Expand
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