• Publications
  • Influence
Fine-scale population differentiation and gene flow in a terrestrial salamander (Plethodon cinereus) living in continuous habitat
Several recent studies have shown that amphibian populations may exhibit high genetic subdivision in areas with recent fragmentation and urban development. Less is known about the potential forExpand
  • 110
  • 13
  • Open Access
Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration
BackgroundMicroarray analysis and 454 cDNA sequencing were used to investigate a centuries-old problem in regenerative biology: the basis of nerve-dependent limb regeneration in salamanders.Expand
  • 251
  • 5
  • Open Access
Early gene expression during natural spinal cord regeneration in the salamander Ambystoma mexicanum
In contrast to mammals, salamanders have a remarkable ability to regenerate their spinal cord and recover full movement and function after tail amputation. To identify genes that may be associatedExpand
  • 80
  • 4
  • Open Access
Effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the Mexican axolotl (Ambystoma)
BackgroundThyroid hormones (TH) induce gene expression programs that orchestrate amphibian metamorphosis. In contrast to anurans, many salamanders do not undergo metamorphosis in nature. However,Expand
  • 44
  • 3
  • Open Access
Cognitive and behavioral development up to 4 years after early right frontal lobe lesion.
The neuropsychological consequences of hemorrhage and surgical repair of a deep right frontal arteriovenous malformation in a 7‐year‐old boy are described. The lesion involved the right dorsolateralExpand
  • 51
  • 3
Transcriptional response of Mexican axolotls to Ambystoma tigrinum virus (ATV) infection
BackgroundVery little is known about the immunological responses of amphibians to pathogens that are causing global population declines. We used a custom microarray gene chip to characterize geneExpand
  • 35
  • 2
  • Open Access
A model of transcriptional and morphological changes during thyroid hormone-induced metamorphosis of the axolotl.
Anuran (frog) metamorphosis has long-served as a model of how thyroid hormones regulate post-embryonic development in vertebrates. However, comparatively little is known about urodele (salamander)Expand
  • 43
  • 1
Microarray analysis identifies keratin loci as sensitive biomarkers for thyroid hormone disruption in the salamander Ambystoma mexicanum.
Ambystomatid salamanders offer several advantages for endocrine disruption research, including genomic and bioinformatics resources, an accessible laboratory model (Ambystoma mexicanum), and naturalExpand
  • 28
  • 1
  • Open Access
Induction of metamorphosis in axolotls (Ambystoma mexicanum).
  • 22
  • 1
Linear Methods for Analysis and Quality Control of Relative Expression Ratios from Quantitative Real-Time Polymerase Chain Reaction Experiments
Relative expression quantitative real-time polymerase chain reaction (RT-qPCR) experiments are a common means of estimating transcript abundances across biological groups and experimental treatments.Expand
  • 23
  • 1
  • Open Access