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Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors.
The results are interpreted in terms of metabolic control of the biosynthesis of deoxynucleotides by these nucleoside triphosphates serving as regulatory effecters.
Nucleotide metabolism. II. Chromatographic separation of acid-soluble nucleotides.
A survey of the metabolism of orotic acid in the rat.
A preliminary survey of the metabolic pathways followed by erotic acid in the rat is presented, finding the localization of the radioactivity in the nucleic acids and pyrimidine nucleotides of the liver, transplanted tumors, and internal organs has been determined.
The conversion of orotic acid to undine nucleotides in vitro.
Growth of carcinoma implants in fed and fasted rats.
- G. Lepage, V. Potter, H. Busch, C. Heidelberger, R. B. Hurlbert
- Biology, MedicineCancer research
- 1 February 1952
It was concluded that protein metabolism in the Flexner-Jobling carcinoma is essentially, if not completely, a “one-way passage,”, and that the proteins of this tumor are not available to the host for fuel during starvation.
Anion exchange chromatography of acids of the citric acid cycle.
This study is-an extension of the use of ion exchange resins to the separation of acids of the Krebs cycle by using these resins for chromatographic separation of individual amino acids.
Induction of limited DNA damage by the antitumor agent Cain's acridine.
The results are interpreted to indicate that AMSA causes alkali-sensitive lesions of DNA at a limited number of sites; this effect correlates with the antitumor action of the drug and with other work showing long-term damage to chromosome structure.
Partial purification and characterization of tumor and liver S-adenosylmethionine synthetases.
The tumor enzyme did not appear to require sulfhydryl agents for the activity to be detected, was inhibited by S-adenosylmethionine, and was inhibited to a greater degree by tripolyphosphate, suggesting selective inhibition of tumor growth by chemotherapeutic agents.
The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).
Amination of uridine nucleotides to cytidine nucleotides by soluble mammalian enzymes; role of glutamine and guanosine nucleotides.