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Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors.
The effects of several nucleoside triphosphates as activators and inhibitors of the enzymic reduction of ribonucleoside diphosphates to deoxynucleotides was studied. The enzyme was a partially… Expand
Nucleotide metabolism. II. Chromatographic separation of acid-soluble nucleotides.
Role of ribosomal RNA methylases in the regulation of ribosome production in mammalian cells.
The activity of rRNA methylases was stimulated by high-energy precursors of RNA (ribonucleoside triphosphates) and inhibited by degradation products of RNA (ribonucleotides and oligoribonucleotides).… Expand
The conversion of orotic acid to undine nucleotides in vitro.
Growth of carcinoma implants in fed and fasted rats.
- G. Lepage, V. Potter, H. Busch, C. Heidelberger, R. B. Hurlbert
- Biology, Medicine
- Cancer research
- 1 February 1952
Control rats and rats bearing multiple implants of Flexner-Jobling carcinoma were fed or fasted and the weight changes determined for tumors and normal tissues. Glycine-2-C14 was used to label the… Expand
Anion exchange chromatography of acids of the citric acid cycle.
The demonstration of the accumulation of citrate in vivo in the presence of fluoroacetate and the specific modification of this effect produced in various organs by the injection of malonate (14)… Expand
A survey of the metabolism of orotic acid in the rat.
Orotic acid has been demonstrated to be an effective precursor of the nucleic acid pyrimidines in animal tissues, both in viva (1, 2) and in vitro (3,4). It is a growth-stimulating factor for certain… Expand
Induction of limited DNA damage by the antitumor agent Cain's acridine.
Abstract The antitumor drug methanesulfonyl-m-anisidine, 4′-(9-acridinylamino) monohydrochloride (AMSA) (Cain9s acridine, NSC 141549), causes a limited, partially reversible decrease in size of the… Expand
Partial purification and characterization of tumor and liver S-adenosylmethionine synthetases.
The S-adenosylmethionine synthetase activities of rat liver and Novikoff ascites tumor have been partially purified and characterized by chromatographic behavior, kinetic analysis, sulfhydryl… Expand
The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).