R. B. Gammill

Publications96
h-index17
Citations854
Highly Influential Citations5
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Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
  • 79
  • 2
A New and Efficient Synthesis of 3-Halogenated 4H-1-Benzopyran-4-ones
  • 48
  • 1
Diels-Alder reactions of 1,1-dimethoxy-3-trimethylsilyloxy-1,3-butadiene
  • 33
  • 1
A novel entry to substituted chromones and furochromones through cyclopropane intermediates.
Abstract Addition of several carbon nucleophiles to 3-bromochromone 1 and 6-bromofurochromone 2 yield interestingly substituted δ-pyrone ring analogues.
  • 7
  • 1
Inhibition of fibroblast and smooth muscle cell proliferation and migration in vitro by a novel aminochromone U-67154.
Medial smooth muscle cell migration and neointimal proliferation are primary contributors to the delayed restenosis that occurs after percutaneous transluminal coronary angioplasty. In this study, we… Expand
  • 10
U-73482: a novel ACAT inhibitor that elevates HDL-cholesterol, lowers plasma triglyceride and facilitates hepatic cholesterol mobilization in the rat.
U-73482, a novel acylCoA:cholesterol acyltransferase (ACAT) inhibitor with systemic activity, has been evaluated for its effects on a variety of lipid metabolic parameters in the rat. The compound… Expand
  • 18
Substituted pyrazinones, a new class of allosteric modulators for gamma-aminobutyric acidA receptors.
We discovered substituted pyrazinones as a new class of allosteric modulators of gamma-aminobutyric acid (GABA)A receptors. Prototype pyrazinones, U-92813… Expand
  • 16
Derivatives of 1-methoxy-3-trimethylsilyloxy-1,3-butadiene for Diels-Alder reactions
  • 43
Antiatherosclerotic agents. A structurally novel bivalent inhibitor of acylCoA:cholesterol O-acyltransferase with systemic activity.
  • 22
Synthesis and biological evaluation of antiplatelet 2-aminochromones.
The synthesis and biological evaluation of a series of antiplatelet 2-morpholinylchromones has been described. Modification of the C-7 phenylmethoxy group of… Expand
  • 26