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Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
Diels-Alder reactions of 1,1-dimethoxy-3-trimethylsilyloxy-1,3-butadiene
A novel entry to substituted chromones and furochromones through cyclopropane intermediates.
Abstract Addition of several carbon nucleophiles to 3-bromochromone 1 and 6-bromofurochromone 2 yield interestingly substituted δ-pyrone ring analogues.
Inhibition of fibroblast and smooth muscle cell proliferation and migration in vitro by a novel aminochromone U-67154.
Medial smooth muscle cell migration and neointimal proliferation are primary contributors to the delayed restenosis that occurs after percutaneous transluminal coronary angioplasty. In this study, we… Expand
U-73482: a novel ACAT inhibitor that elevates HDL-cholesterol, lowers plasma triglyceride and facilitates hepatic cholesterol mobilization in the rat.
U-73482, a novel acylCoA:cholesterol acyltransferase (ACAT) inhibitor with systemic activity, has been evaluated for its effects on a variety of lipid metabolic parameters in the rat. The compound… Expand
Substituted pyrazinones, a new class of allosteric modulators for gamma-aminobutyric acidA receptors.
We discovered substituted pyrazinones as a new class of allosteric modulators of gamma-aminobutyric acid (GABA)A receptors. Prototype pyrazinones, U-92813… Expand
Derivatives of 1-methoxy-3-trimethylsilyloxy-1,3-butadiene for Diels-Alder reactions
Antiatherosclerotic agents. A structurally novel bivalent inhibitor of acylCoA:cholesterol O-acyltransferase with systemic activity.
Synthesis and biological evaluation of antiplatelet 2-aminochromones.
- J. Morris, D. Wishka, +7 authors C. Jacob
- Chemistry, Medicine
- Journal of medicinal chemistry
- 9 July 1993
The synthesis and biological evaluation of a series of antiplatelet 2-morpholinylchromones has been described. Modification of the C-7 phenylmethoxy group of… Expand