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Safety evaluation of phytosterol esters. Part 5. Faecal short-chain fatty acid and microflora content, faecal bacterial enzyme activity and serum female sex hormones in healthy normolipidaemic
The daily consumption of a margarine enriched with 8.6 g vegetable oil phytosterols did not affect the bacterial profile or the metabolic activities of the gut microflora, nor did it result in biologically relevant effects on serum female sex hormone levels. Expand
Studies on the discontinuous N-oxidation of trimethylamine among Jordanian, Ecuadorian and New Guinean populations.
Observations suggest that a compromised ability to N-oxidize trimethylamine is detectable in several ethnic groups and that this polymorphic phenomenon may have a widespread existence. Expand
Disclosure of the metabolic retroversion of trimethylamine N‐oxide in humans: A pharmacogenetic approach
It is proposed that the use of human metabolic variants allows both a qualitative and quantitative assessment of retroverted metabolism as occurs with TMAO, and the principle may usefully be applied in other situations. Expand
Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).
Southern blot hybridization of human genomic DNA suggests that the protein is encoded by a single gene, which has been designated FMO1 and mapped to chromosome 1, indicating that in man the enzyme is subject to developmental regulation. Expand
Metabolic oxidation phenotypes as markers for susceptibility to lung cancer
It is concluded that the gene controlling debrisoquine 4-hydroxylation may be a host genetic determinant of susceptibility to lung cancer in smokers and that it represents a marker to assist in assessing individual risk. Expand
A Genetic polymorphism of the N‐oxidation of trimethylamine in humans
The study of the families of the two propositi, as well as those of two identified subjects with trimethylaminuria, under both normal dietary conditions and after oral TMA challenge strongly indicates that the conditions of impaired N‐oxidation is inherited as a recessive trait. Expand
The effects of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with “low” or “high” cholesterol levels
A human volunteer study was conducted to test the effect of vitamin C supplementation on biomarkers of oxygen radical‐mediated damage in individuals with a range of serum cholesterol levels.
The fish odour syndrome: biochemical, familial, and clinical aspects.
The fish odour syndrome can be inherited in an autosomal recessive fashion and should be considered as a possible causative factor in patients complaining of body malodour. Expand
Genetic polymorphism of trimethylamine N-oxidation.
Primary trimethylaminuria is a food idiosyncracy known to represent a pharmacogenetic polymorphism and which is secondary to other factors such as renal or hepatic disease or overload with trimmedethylamine precursors. Expand
Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers.
It is concluded that quinidine, but not its diastereoisomer quinine, is a potent selective inhibitor of the in vivo oxidation of debrisoquine and can produce an artifactual PM phenocopy in persons who are phenotypically extensive metaboliser (EM) phenotype status. Expand