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A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors. Expand
An Olfactory Sensory Map in the Fly Brain
We have isolated the "complete" repertoire of genes encoding the odorant receptors in Drosophila and employ these genes to provide a molecular description of the organization of the peripheralExpand
The neuronal architecture of the mushroom body provides a logic for associative learning
The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory. Expand
Visualizing an Olfactory Sensory Map
A genetic approach is developed to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the Olfactory bulb, which provides direct support for a model in which a topographic map of receptor activation encodes odor quality in the ofactory bulb. Expand
Two-Photon Calcium Imaging Reveals an Odor-Evoked Map of Activity in the Fly Brain
A sensitive imaging system in the Drosophila brain that couples two-photon microscopy with the specific expression of the calcium-sensitive fluorescent protein, G-CaMP is developed, demonstrating that the response pattern of a given glomerulus is a function of the specificity of a single odorant receptor. Expand
A novel family of genes encoding putative pheromone receptors in mammals
Sequence analysis indicates that a family of about 30 putative receptor genes comprise a novel family of seven transmembrane domain proteins unrelated to the receptors expressed in the MOE, likely to encode mammalian pheromone receptors. Expand
A Spatial Map of Olfactory Receptor Expression in the Drosophila Antenna
A novel family of seven transmembrane domain proteins, encoded by 100 to 200 genes, that is likely to represent the family of Drosophila odorant receptors are identified and may ultimately afford a system to understand the mechanistic link between odor recognition and behavior. Expand
A Chemosensory Gene Family Encoding Candidate Gustatory and Olfactory Receptors in Drosophila
In situ hybridization and transgene experiments that reveal expression of candidate gustatory receptors in both gustatory and olfactory neurons in adult flies and larvae provide insight into the diversity of chemosensory recognition and an initial view of the representation of gustatory information in the fly brain. Expand
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
In the fruit fly, Drosophila, olfactory sensory neurons expressing a given receptor project to spatially invariant loci in the antennal lobe to create a topographic map of receptor activation, which is represented in higher sensory centers in the brain by projection neurons that innervate the same glomerulus. Expand
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
The studies support a mechanism of AIDS virus infection that initially involves the specific interaction of theAIDS virus with T4 molecules on the cell surface, and find that the T4 gene is expressed in the brain as well as in lymphoid cells, providing an explanation for the dual neurotropic and lymphotropic character of the AIDS virus. Expand