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Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase.
Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.
It is demonstrated that this series of GC inhibitors with a quinazoline core can improve the translocation of GC to the lysosome in patient-derived cells.
Stereoselective preparation of (Z)-2-(trialkylsilyloxy)-2-alkenals by retrocycloaddition reactions of 4H-4-Alkyl-5-(trialkylsilyloxy)-1,3-dioxins. Useful reactants for Lewis acid catalyzed [4 + 3]…
Retrocycloadditions of 4H-4-alkyl-5-(trialkylsilyloxy)-1,3-dioxins proceed smoothly in refluxing toluene to afford (Z)-2-alkenals with complete stereoselectivity.
Synthesis of (Z)-2-acyl-2-enals via retrocycloadditions of 5-acyl-4-alkyl-4H-1,3-dioxins: application in the total synthesis of the cytotoxin (+/-)-euplotin A.
Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators.
Total synthesis of the sesquiterpene (+/-)-illudin C via an intramolecular nitrile oxide cycloaddition.
[reaction: see text] A convergent total synthesis of illudin C is described. The tricyclic ring system of the natural product was quickly assembled from cyclopropane and cyclopentene precursors via a…
ChemInform Abstract: Synthesis of (Z)-2-Acyl-2-enals via Retrocycloadditions of 5-Acyl-4-alkyl-4H-1,3-dioxins: Application in the Total Synthesis of the Cytotoxin (.+-.)-Euplotin A (X).
Stereoselective synthesis of (Z)-2-acyl-2-enals via retrocycloadditions of 5-acyl-4-alkyl-4H-1,3-dioxins: Applications in natural product synthesis
- R. Aungst
- 23 May 2007
Total Synthesis of the Sesquiterpene (.+‐.)‐Illudin C via an Intramolecular Nitrile Oxide Cycloaddition.