Neurotoxic cyanobacterial toxins.
- R. Aráoz, J. Molgó, N. Tandeau de Marsac
- 1 October 2010
Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon.
- P. Hess, Eric Abadie, Z. Amzil
- Biology, Environmental ScienceToxicon
- 1 December 2013
Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism
- Y. Bourne, Z. Radić, P. Marchot
- Biology, ChemistryProceedings of the National Academy of Sciences
- 11 March 2010
Analysis of 13-desmethyl spirolide C and gymnodimine A by binding and voltage-clamp recordings on muscle-type α12βγδ and neuronal α3β2 and α4β2 nicotinic acetylcholine receptors reveals subnanomolar affinities, potent antagonism, and limited subtype selectivity.
Neurotoxins in axenic oscillatorian cyanobacteria: coexistence of anatoxin-a and homoanatoxin-a determined by ligand-binding assay and GC/MS.
- R. Aráoz, H. Nghiêm, R. Rippka, N. Palibroda, N. T. de Marsac, M. Herdman
- Biology, ChemistryMicrobiology
- 1 April 2005
The latter results suggest that regulatory differences in at least some of the cyanobacterial strains may account for the preferential synthesis of only one of the two neurotoxins or for their simultaneous occurrence.
Total synthesis of pinnatoxins A and G and revision of the mode of action of pinnatoxin A.
- R. Aráoz, D. Servent, A. Zakarian
- Biology, ChemistryJournal of the American Chemical Society
- 13 July 2011
The comprehensive electrophysiological, biochemical, and computational studies support the view that the spiroimine subunit of pinnatoxins is critical for blocking nicotinic acetylcholine receptor subtypes, as evidenced by analyzing the effect of a synthetic analogue of pnatoxin A containing an open form of the imine ring.
Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.
- C. Stivala, É. Benoit, A. Zakarian
- Chemistry, BiologyNatural product reports (Print)
- 26 February 2015
This review article aims to provide an account of chemistry, biology, and toxicology of CI toxins from their discovery to the present day.
Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization.
- N. Vilariño, E. S. Fonfría, J. Molgó, R. Aráoz, L. Botana
- Biology, ChemistryAnalytical Chemistry
- 1 April 2009
This inhibition assay is capable of gymnodimine-A and 13-desmethyl C spirolide detection in mussel extracts with enough sensitivity and specificity to quantify these toxins in the range of 50-2000 microg/kg and 70-700 microg /kg of shellfish meat, respectively.
Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors
- J. Molgó, P. Marchot, D. Servent
- Biology, ChemistryJournal of Neurochemistry
- 21 March 2017
An overview of the toxicological profile of the fast‐acting, lipophilic macrocyclic imine toxins, an emerging family of organic compounds associated with algal blooms, shellfish contamination and neurotoxicity, and their implications for the shellfish food industry is presented.
Ligand-binding assays for cyanobacterial neurotoxins targeting cholinergic receptors
- R. Aráoz, N. Vilariño, L. Botana, J. Molgó
- Biology, ChemistryAnalytical and Bioanalytical Chemistry
- 19 March 2010
The ligand-binding assays developed for detection of cyanobacterial and algal neurotoxins targeting the nicotinic acetylcholine receptors and for high-throughput screening of novel nicotinics agents are reviewed.