Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.
- S. Cao, Andrew Norris, D. Kingston
- ChemistryJournal of Natural Products
- 31 January 2007
Three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C, showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.
Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.
- Brent J. Yoder, S. Cao, D. Kingston
- BiologyJournal of Natural Products
- 28 February 2007
Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated stilbenes, schweinfurthins E-H (1-4), and one new…
Two new triterpene esters from the twigs of Brachylaena ramiflora from the Madagascar rainforest.
- V. S. Chaturvedula, J. K. Schilling, J. Miller, R. Andriantsiferana, V. Rasamison, D. Kingston
- ChemistryJournal of Natural Products
- 12 July 2002
Bioassay-guided fractionation of a CH(2)Cl(2)/MeOH extract of the small twigs of Brachylaena ramiflora var. ramiflora resulted in the isolation of the two new triterpene esters 1 and 2 and five known…
Cytotoxic compounds from Mundulea chapelieri from the Madagascar Rainforest.
- S. Cao, J. K. Schilling, J. Miller, R. Andriantsiferana, V. Rasamison, D. Kingston
- ChemistryJournal of Natural Products
- 8 January 2004
Bioassay-guided fractionation of methanolic extracts of Mundulea chapelieri resulted in the isolation of two new flavonoids, isomundulinol and 3-deoxy-MS-II, which were tested for cytotoxicity against the A2780 human ovarian cancer cell line.
Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest.
- S. Cao, P. Brodie, D. Kingston
- ChemistryJournal of Natural Products
- 27 February 2007
A bioassay-guided fractionation of the EtOH extract of the Madagascan plant Terminalia calcicola led to the isolation of two new cytotoxic xanthones, termicalcicolanone A andtermicalcIColanone B, which showed modest antiproliferative activity toward the human ovarian cancer cell line.
Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.
- Russell B Williams, Andrew Norris, D. Kingston
- ChemistryJournal of Natural Products
- 19 January 2007
Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These…
Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.
- S. Cao, R. Guza, J. Miller, R. Andriantsiferana, V. Rasamison, D. Kingston
- ChemistryJournal of Natural Products
- 25 May 2004
Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridOCarpusic acids A-E (1-5), which established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation the structures of the new compounds 1-5.
Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest.
- Sampada S. Karkare, Eba Adou, D. Kingston
- ChemistryJournal of Natural Products
- 8 November 2007
Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boiv inides 1-6, which showed significant antiproliferative activity against the A2780 human ovarian cancer cell line.
Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae)
- Brent J. Yoder, S. Cao, D. Kingston
- Chemistry, BiologyNatural Product Research
- 1 January 2007
A new cytotoxic hydroxybutanolide, tambouranolide, has been isolated by solid phase extraction from an ethanol extract of the dried roots of a species of Tambourissa (Monimiaceae) from the Madagascar…
Cytotoxic diterpenes from Cassipourea madagascariensis from the Madagascar rainforest.
- V. S. Chaturvedula, Andrew Norris, D. Kingston
- ChemistryJournal of Natural Products
- 7 January 2006
Bioassay-directed fractionation of ethanol extracts of the roots and leaves of the plant Cassipourea madagascariensis resulted in the isolation of the two new terpenoids cassipourol and cassipouryl acetate, which showed moderate cytotoxic activity, while the three known compounds were weakly active.
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