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Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.
TLDR
Three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C, showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.
Cytotoxic compounds from Mundulea chapelieri from the Madagascar Rainforest.
TLDR
Bioassay-guided fractionation of methanolic extracts of Mundulea chapelieri resulted in the isolation of two new flavonoids, isomundulinol and 3-deoxy-MS-II, which were tested for cytotoxicity against the A2780 human ovarian cancer cell line.
Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest.
TLDR
A bioassay-guided fractionation of the EtOH extract of the Madagascan plant Terminalia calcicola led to the isolation of two new cytotoxic xanthones, termicalcicolanone A andtermicalcIColanone B, which showed modest antiproliferative activity toward the human ovarian cancer cell line.
Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.
Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These
Two new triterpene esters from the twigs of Brachylaena ramiflora from the Madagascar rainforest.
Bioassay-guided fractionation of a CH(2)Cl(2)/MeOH extract of the small twigs of Brachylaena ramiflora var. ramiflora resulted in the isolation of the two new triterpene esters 1 and 2 and five known
Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest.
TLDR
Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boiv inides 1-6, which showed significant antiproliferative activity against the A2780 human ovarian cancer cell line.
Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.
TLDR
Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridOCarpusic acids A-E (1-5), which established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation the structures of the new compounds 1-5.
Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.
Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated stilbenes, schweinfurthins E-H (1-4), and one new
Cytotoxic diterpenes from Cassipourea madagascariensis from the Madagascar rainforest.
TLDR
Bioassay-directed fractionation of ethanol extracts of the roots and leaves of the plant Cassipourea madagascariensis resulted in the isolation of the two new terpenoids cassipourol and cassipouryl acetate, which showed moderate cytotoxic activity, while the three known compounds were weakly active.
New cytotoxic terpenoids from the wood of Vepris punctata from the Madagascar Rainforest.
TLDR
The structures of the two new terpenoids 1 and 2 were established on the basis of 1D and 2D NMR spectroscopic data interpretation and chemical modifications and tested against the A2780 human ovarian cancer cell line.
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