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Case Definition and Phenotype Standardization in Drug‐Induced Liver Injury
An international DILI Expert Working Group of clinicians and scientists reviewed current DILi terminology and diagnostic criteria so as to develop more uniform criteria that would define and characterize the spectrum of clinical syndromes that constitute D ILI. Expand
Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period.
Patients with drug-induced hepatocellular jaundice have 11.7% chance of progressing to death or transplantation, and amoxicillin-clavulanate stands out as the most common drug related to DILI. Expand
The influence of older age in the cholestatic/mixed expression of the liver injury, as well as the independent association of female gender, older age, aspartate aminotransferase levels/hepatocellular type of damage and high bilirubin levels with the risk of fulminant liver failure/death are underlined. Expand
Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients.
Insulin resistance, fibrosis, and genotype are independent predictors of the response to antiviral therapy in chronic hepatitis C patients treated with peginterferon plus ribavirin. Expand
Drug-induced liver injury: Interactions between drug properties and host factors.
- Minjun Chen, A. Suzuki, J. Borlak, R. Andrade, M. Lucena
- Biology, Medicine
- Journal of hepatology
- 1 August 2015
Current knowledge on 1) drug properties associated with hepatotoxicity, 2) host factors considered to modify an individuals' risk for DILI and clinical phenotypes, and 3) drug-host interactions are summarized. Expand
Standardization of nomenclature and causality assessment in drug‐induced liver injury: Summary of a clinical research workshop
It was concluded that multicenter referral networks enrolling patients with suspected DILI according to standardized methodologies are needed and a web‐of‐knowledge database that provides concise, reliable, and updated information on cases of liver injury due to drugs and herbal and dietary supplements was established. Expand
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.
Class I and II HLA genotypes affect susceptibility to AC-DILI, indicating the importance of the adaptive immune response in pathogenesis. Expand
The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug‐induced liver injury
Although an overlap of histologic findings exists for AIH and DILI, sufficient differences exist so that pathologists can use the pattern of injury to suggest the correct diagnosis. Expand
Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.
Traditional Chinese medicines, herbal and dietary supplements, and antituberculosis drugs were the leading causes of DILI in mainland China and the annual incidence was estimated to be 23.80 per 100,000 persons; higher than that reported from Western countries. Expand
Peginterferon-alfa2a plus ribavirin for 48 versus 72 weeks in patients with detectable hepatitis C virus RNA at week 4 of treatment.
Extension of treatment with peginterferon-alfa2a plus ribavirin from 48 to 72 weeks significantly increases the rate of SVR in patients with detectable viremia at week 4 of treatment. Expand