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Activation of a Novel Calcium-dependent Protein-tyrosine Kinase
TLDR
In summary, cells expressing CADTK/PYK2 appear to have two alternative JNK activation pathways: one stress-activated and the other calcium-dependent. Expand
Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.
TLDR
The structure of a-factor is defined as replacement of the farnesyl by a methyl group leads to a partial reduction in specific biological activity of the a-Factor, whereas hydrolysis of the carboxyl-terminal methyl ester causes a complete loss of activity. Expand
Sequencing and characterization of the soybean leaf metalloproteinase : structural and functional similarity to the matrix metalloproteinase family.
TLDR
Comparison of the primary amino acid sequence with other zinc proteinases revealed the enzyme to be a new member of the matrix metalloproteinase (MMP) family of enzymes and its cognate inhibitors predates the divergence of plants and animals. Expand
Amino acid sequence of bacteriorhodopsin.
TLDR
The complete primary structure of the purple membrane protein bacteriorhodopsin, which contains 248 amino acid residues, has been determined and the present sequence differs from that recently reported by Ovchinnikov and coworkers with respect to an additional tryptophan and several amino acid assignments. Expand
DNA adduct formation in B6C3F1 mice and Fischer-344 rats exposed to 1,2,3-trichloropropane.
TLDR
Although relatively high concentrations of DNA adducts were detected in target organs, several nontarget sites also contained high adduct levels, and the data suggest that factors in addition to adduct formation may be important in TCP-induced carcinogenesis. Expand
Partial primary structure of bacteriorhodopsin: sequencing methods for membrane proteins.
TLDR
The sequence of 102 amino acid residues from the NH2 terminus and that of 39 amino acid residue from the COOH terminus of bacteriorhodopsin have been determined by a judicious combination of mass spectrometric peptide sequencing and automated Edman degradation. Expand
Comprehensive on-line LC/LC/MS of proteins.
TLDR
This system uses cation-exchange chromatography followed by reversed-phase chromatography (RPLC) for the separation of protein mixtures and can be rapidly separated, desalted, and analyzed for molecular weight in less than 2 h. Expand
Primary structure of the lambda repressor.
The complete covalent structure of the bacteriophage lambda repressor has been determined by sequential Edman degradation, gas chromatographic-mass spectrometric peptide sequencing, and DNAExpand
Conformation of cytochrome c studied by deuterium exchange-electrospray ionization mass spectrometry.
TLDR
Neither charge-state distribution nor deuterium exchange rate alone is a sufficient indicator of protein conformation, and the data suggest that at least two conformations can have identical charge- state distributions, but have different exchange rates. Expand
The Mass Spectrometry of Helical Unfolding in Peptides
TLDR
Two model peptides, melittin and a growth hormone releasing factor analog, have been studied by mass spectrometry and tandem mass Spectrometry during the course of their deuterium exchange, indicating multiple populations of exchangeable protons. Expand
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