R. Anda

Publications154
h-index75
Citations45,002
Highly Influential Citations2,311
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Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study.
TLDR
A strong graded relationship is found between the breadth of exposure to abuse or household dysfunction during childhood and multiple risk factors for several of the leading causes of death in adults. Expand
Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study.
TLDR
A strong graded relationship was found between the breadth of exposure to abuse or household dysfunction during childhood and multiple risk factors for several of the leading causes of death in adults. Expand
The enduring effects of abuse and related adverse experiences in childhood
TLDR
The graded relationship of the ACE score to 18 different outcomes in multiple domains theoretically parallels the cumulative exposure of the developing brain to the stress response with resulting impairment in multiple brain structures and functions. Expand
Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: the adverse childhood experiences study.
TLDR
The persistent graded relationship between the ACE score and initiation of drug use for 4 successive birth cohorts dating back to 1900 suggests that the effects of adverse childhood experiences transcend secular changes such as increased availability of drugs, social attitudes toward drugs, and recent massive expenditures and public information campaigns to prevent drug use. Expand
Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study.
TLDR
A powerful graded relationship exists between adverse childhood experiences and risk of attempted suicide throughout the life span, and alcoholism, depressed affect, and illicit drug use, which are strongly associated with such experiences, appear to partially mediate this relationship. Expand
Adverse childhood experiences and the risk of depressive disorders in adulthood.
TLDR
The results suggest that exposure to ACEs is associated with increased risk of depressive disorders up to decades after their occurrence, and early recognition of childhood abuse and appropriate intervention may play an important role in the prevention of depressive Disorders throughout the life span. Expand
The interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction.
TLDR
The study provides strong evidence that ACEs are interrelated rather than occurring independently, and collecting information about exposure to other ACEs is advisable for studies that focus on the consequences of a specific ACE. Expand
Long-term consequences of childhood sexual abuse by gender of victim.
TLDR
Findings strongly indicate that boys and girls are vulnerable to this form of childhood maltreatment; the similarity in the likelihood for multiple behavioral, mental, and social outcomes among men and women suggests the need to identify and treat all adults affected by CSA. Expand
Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: results from the adverse childhood experiences study.
OBJECTIVE This study examined the prevalence of a history of various combinations of childhood maltreatment types (physical abuse, sexual abuse, and witnessing of maternal battering) among adult… Expand
Adverse childhood experiences, alcoholic parents, and later risk of alcoholism and depression.
TLDR
Depression among adult children of alcoholics appears to be largely, if not solely, due to the greater likelihood of having had adverse childhood experiences in a home with alcohol-abusing parents. Expand
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