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HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide.
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance.
The results suggest that circulating clonotypic B-cell populations represent multiple myeloma stem cells, and the relative drug resistance of these cells is mediated by processes that protect normal stem cells from toxic injury.
Comparison of Genetic Variability at Multiple Loci across the Genomes of the Major Subtypes of Kaposi’s Sarcoma-Associated Herpesvirus Reveals Evidence for Recombination and for Two Distinct Types of…
Overall, the results suggest that an original recombination event with a related primate virus from an unknown source introduced exogenous right-hand side ORF-K15(M) sequences into an ancient M form of HHV8, followed by eventual acquisition into the subtype C lineage of the modern P-form of theHHV8 genome and subsequent additional, more recent transfers by homologous recombination events into several subtype A and B lineages.
A New Primary Effusion Lymphoma-Derived Cell Line Yields a Highly Infectious Kaposi's Sarcoma Herpesvirus-Containing Supernatant
Viral supernatant from JSC-1 was much more efficient at infecting primary human dermal microvascular endothelial cells (DMVECs) with KSHV than supernatants from BC-3 or BCP-1 PEL cell lines.
Epstein-Barr virus in AIDS-related primary central nervous system lymphoma
Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation.
- A. Bedi, C. Miller, R. Jones
- Medicine, BiologyJournal of clinical oncology : official journal…
- 1 May 1995
Mesna and forced diuresis are equally effective in abrogating the urothelial toxicity of preparative regimens for BMT and strategies aimed at the prevention or elimination of viruria in BK seropositive recipients are warranted.
Linkage between STAT Regulation and Epstein-Barr Virus Gene Expression in Tumors
It is hypothesized that chronic or aberrant STAT activation may be both a necessary and predisposing event for EBV-driven tumorigenesis in immunocompetent individuals.
Epstein‐Barr virus‐associated Hodgkin's disease: Epidemiologic characteristics in international data
It is suggested that age, sex, ethnicity and the physiologic effects of poverty may represent biologic modifiers of the EBV association and confirmed that this association is strongly but variably linked to histologic subtype.
Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial…
The addition of rituximab to CHOP in patients with HIV-NHL may be associated with improved tumor responses, however, these benefits may be offset by an increase in infectious deaths, particularly in those individuals with CD4(+) lymphocyte counts less than 50/mm(3).
Comparison of outcomes of HLA-matched related, unrelated, or HLA-haploidentical related hematopoietic cell transplantation following nonmyeloablative conditioning for relapsed or refractory Hodgkin…