Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
Anti-inflammatory effects of aspirin and sodium salicylate.
Absorption and metabolism of capsaicinoids following intragastric administration in rats
- J. Donnerer, R. Amann, R. Schuligoi, F. Lembeck
- Biology, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 1 September 1990
It can be concluded that rapid hepatic metabolization limits systemic pharmacological effects of enterally absorbed capsaicin.
Intraplantar injection of nerve growth factor into the rat hind paw: local edema and effects on thermal nociceptive threshold
Ruthenium red as a capsaicin antagonist.
Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach
Galanin and vasopressin coexist in the rat hypothalamo-neurohypophyseal system.
Using indirect immunofluorescence methods and antisera raised against galanin (GAL) and vasopressin (VP), we have demonstrated both peptides coexisting in the very same cell bodies in the supraoptic…
Stimulation by nerve growth factor of neuropeptide synthesis in the adult rat in vivo: bilateral response to unilateral intraplantar injections
Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia.
- T. Egger, R. Schuligoi, A. Wintersperger, R. Amann, E. Malle, W. Sattler
- BiologyBiochemical Journal
- 1 March 2003
The results suggest that alpha TocH activates microglial PP2A activity and thereby silences an LPS-activated PKC/ERK/NF kappa B signalling cascade resulting in significantly attenuated COX-2 protein synthesis, implying that alphaTocH could induce quiescence to pathways that are associated with acute or chronic inflammatory conditions in the central nervous system.