Inhibition of in vivo tumor growth by a monoclonal IgM antibody recognizing tumor cell surface carbohydrates.
- J. Gil, R. Alvarez, J. Subiza
- BiologyCancer Research
- 15 November 1990
The results indicate that some IgM molecules recognizing cell surface carbohydrates may participate in in vivo tumor suppression by a macrophage-dependent mechanism.
Impaired production and lack of secretion of interleukin 1 by human breast milk macrophages.
- J. Subiza, C. Rodríguez, A. Figueredo, P. Mateos, R. Alvarez, E. G. de la Concha
- Biology, MedicineClinical and Experimental Immunology
- 1 March 1988
It is concluded that HMMø produce four or five times less IL-1 than HMo in response to LPS stimulus and are completely unable to release theIL-1 produced.
IgM response and resistance to ascites tumor growth
- J. Subiza, J. Coll, R. Alvarez, M. Valdivieso, E. G. Concha
- BiologyCancer Immunology and Immunotherapy
- 2004
IgM reactivity to EAT cells was completely abolished by previous cell trypsinization, and its susceptibility to β-galactosidase and particularly to a mild periodate oxidation, suggested that determinants recognized by the IgM against the EAT cell surface are carbohydrate in nature.
[Circulating immune complexes in the serum of tumor patients].
- R. Alvarez, A. García Gómez, J. Subiza, J. Dominguez, A. Bootello, J. Coll
- Medicine, BiologyRevista espanola de oncologia
- 1982
The conditions for the detection of circulating immune complexes (CIC) were established by combination of polyethylene glycol precipitation with a nephelometric determination on the precipitate of endogenous C1q, allowing to characterize tumour specific antigens.