• Publications
  • Influence
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
The synthesis and exploration of novel butyrophenones have led to the identification of a diazepane analogue of haloperidol, 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-oneExpand
  • 32
  • 1
Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species.
The long-term, irreversible, Parkinsonism-like side effects of haloperidol have been speculated to involve several mechanisms. More recently, it has been speculated that the metabolic transformationExpand
  • 35
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.
Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previousExpand
  • 9
Studies on the Mechanism of Base-Catalyzed Decomposition of Bicyclic Endoperoxides
Kornblum and Delamare showed the first decomposition of dialkyl peroxides by base-catalyzed rearrangement. They reported that 1-[1-(tert -butylperoxy)ethyl] benzene 1 gives acetophenone andExpand
  • 13
  • PDF
Deprotecting dithiane-containing alkaloids.
  • 26
Cyclic alkenenitriles: chemoselective oxonitrile cyclizations.
Potassium tert-butoxide triggers the chemoselective cyclization between nitrile anions and remote, enolizable carbonyl groups, despite the acidity difference favoring enolate formation and additionExpand
  • 19
Photooxygenation of azidoalkyl furans: catalyst-free triazole and new endoperoxide rearrangement.
Photooxygenation of azidoalkyl furans has revealed both a novel triazole formation method and a unique endoperoxide rearrangement. The key step of this method is a 3 + 2 cycloaddion of the azide toExpand
  • 11
  • PDF
A novel one-pot conversion of allyl alcohols into primary allyl halides mediated by acetyl halide
A new and simple method for the synthesis of the primary allyl chlorides and bromides 9–16 from the secondary or tertiary allyl alcohols 3–8 and acyl halide was developed (Scheme 2, Table 1).Expand
  • 6
Heterogenous Oxidation of [2.2.1] Bridged Bicyclic Alkenes with KMnO4-CuSO4.5H2O: An Alternative Ozonolysis
Abstract Seven [2.2.1] bridged alkenes were cleaved to the corresponding dialdehyde products by neutral heterogenous oxidation with KMnO4-CuSO4.5H2O. While endo, endo-dimethylExpand
  • 14
Enantioselective Installation of Quaternary Centers in Cyclic Oxonitriles
Quaternary centers are rapidly and selectively installed in a series of seven-membered and bridged cyclic oxonitriles through conjugate addition of an alkoxide to chloroalkenenitriles, followed by aExpand
  • 8