R. Aldrich

Publications191
h-index68
Citations18,036
Highly Influential Citations1,248
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Cloning and Functional Characterization of Novel Large Conductance Calcium-activated Potassium Channel β Subunits, hKCNMB3 and hKCNMB4*
We present the cloning and characterization of two novel calcium-activated potassium channel β subunits, hKCNMB3 and hKCNMB4, that are enriched in the testis and brain, respectively. We compare and… Expand
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Coupling between Voltage Sensor Activation, Ca2+ Binding and Channel Opening in Large Conductance (BK) Potassium Channels
To determine how intracellular Ca2+ and membrane voltage regulate the gating of large conductance Ca2+-activated K+ (BK) channels, we examined the steady-state and kinetic properties of mSlo1 ionic… Expand
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Biophysical and molecular mechanisms of Shaker potassium channel inactivation
The potassium channels encoded by the Drosophila Shaker gene activate and inactivate rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and single-channel… Expand
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Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels.
After removal of N-type inactivation in Shaker K channels another inactivation process remains (C-type inactivation). The C-type inactivation time course is reversibly slowed when external [K+]… Expand
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Shaker potassium channel gating. III: Evaluation of kinetic models for activation
Predictions of different classes of gating models involving identical conformational changes in each of four subunits were compared to the gating behavior of Shaker potassium channels without N-type… Expand
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International Union of Pharmacology. LII. Nomenclature and Molecular Relationships of Calcium-Activated Potassium Channels
Potassium-selective channels are the largest and most diverse group of ion channels, represented by some 70 known loci in the mammalian genome. The first cloned potassium channel gene was the… Expand
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Shaker potassium channel gating. II: Transitions in the activation pathway
Voltage-dependent gating behavior of Shaker potassium channels without N-type inactivation (ShB delta 6-46) expressed in Xenopus oocytes was studied. The voltage dependence of the steady-state open… Expand
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Vasoregulation by the β1 subunit of the calcium-activated potassium channel
Small arteries exhibit tone, a partially contracted state that is an important determinant of blood pressure. In arterial smooth muscle cells, intracellular calcium paradoxically controls both… Expand
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Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal region
Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes. We describe two different types of… Expand
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Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels.
Voltage-activated K+ channels are a family of closely related membrane proteins that differ in their gating behavior, conductance, and pharmacology. A prominent and physiologically important… Expand
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