• Publications
  • Influence
Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole.
TLDR
It is concluded that alpha 2-adrenoreceptor stimulation decreases sympathetic activity and decreases ischemic injury in a model of incomplete cerebral ischemia in rats. Expand
The Role of Neuronal Nitric Oxide Synthase in Regulation of Cerebral Blood Flow in Normocapnia and Hypercapnia in Rats
TLDR
The results suggest that the NO synthesized by the action of nNOS participates in regulation of basal CBF and is the major, if not the only, category of NO contributing to the hypercapnic CBF response. Expand
The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats.
TLDR
Results show that propofol improves neurologic outcome and decreases neuronal damage from incomplete cerebral ischemia when compared to fentanyl/N2O. Expand
Cardiovascular effects and acid-base and blood gas changes during laparoscopy.
TLDR
Laroscopy in 10 women with intraperitoneal carbon dioxide insufflation up to 20 mm was accompanied by circulatory stimulation with elevated arterial and central venous blood pressures, tachycardia, hypercarbia, and decrease in pH, suggesting inhibited venous return. Expand
Occurrence of potentially detrimental temperature alterations in hospitalized patients at risk for brain injury.
TLDR
In these hospitalized patients at risk for ongoing brain injury, the incidence of temperature increases within the range reported to worsen neurologic outcome (elevations of 1.0 degree C or more) was very high. Expand
Role of nitric oxide, adenosine,N-methyl-d-aspartate receptors, and neuronal activation in hypoxia-induced pial arteriolar dilation in rats
TLDR
The results imply that severe hypoxia-induced release of NO and ADO, and the accompanying pial arteriolar dilation, are wholly dependent on the capacity to generate action potentials in perivascular nerves. Expand
Nitrous Oxide Markedly Increases Cerebral Cortical Metabolic Rate and Blood Flow in the Goat
TLDR
N2O (at least in goats) is associated with a marked cerebral cortical “activation” and changes in cerebral O2 metabolism (CMRO2) and total and regional CBF (rCBF) are attributed solely to the presence of N2O. Expand
The effects of propofol on cerebral and spinal cord blood flow in rats.
TLDR
Results indicate that propofol maintains CBF and SCBF autoregulation in rats anesthetized with nitrous oxide and fentanyl, and suggest that this drug maintains cerebral blood flow and spinal cord blood flow as a function of mean arterial blood pressure. Expand
Phonocardiography as a monitor of cardiac performance during anesthesia.
TLDR
Perioperative phonocardiography, a simple and noninvasive procedure, merits further investigation as a possible monitor of cardiac performance during anesthesia. Expand
Cardiovascular Effects of Intraperitoneal Insufflation with Carbon Dioxide and Nitrous Oxide in the Dog
TLDR
The data from this study indicate that intraperitoneal insufflation produces serious hemodynamic alterations which are manifested by low cardiac output and elevated total peripheral resistance, and directly measured right atrial pressure cannot be used clinically as an indicator of venous return to the heart since it reflects a composite of pleural and intra-abdominal insUFFlation pressures. Expand
...
1
2
3
4
5
...