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Pig epiblast stem cells depend on activin/nodal signaling for pluripotency and self-renewal.
Activin/Nodal signaling is required for maintaining pluripotency and self-renewal of mouse epiblast stem cells and human embryonic stem cells (hESC). In this study, we investigated whether this… Expand
Intracytoplasmic sperm injection in bovine: effects of oocyte activation, sperm pretreatment and injection technique.
- R. Suttner, V. Zakhartchenko, +6 authors M. Stojković
- Chemistry, Medicine
- 1 October 2000
Intracytoplasmic sperm injection (ICSI) is a very important technique for treating male subfertility and for basic research. The efficiency of ICSI in bovine is very limited because of the necessity… Expand
Principles of early human development and germ cell program from conserved model systems
Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during weeks 2–3 of early post-implantation development. Using in vitro models of hPGC induction, recent studies have… Expand
A gene expression atlas of the domestic pig
BackgroundThis work describes the first genome-wide analysis of the transcriptional landscape of the pig. A new porcine Affymetrix expression array was designed in order to provide comprehensive… Expand
Contrasting Effects of in Vitro Fertilization and Nuclear Transfer on the Expression of mtDNA Replication Factors
Mitochondrial DNA (mtDNA) is normally only inherited through the oocyte. However, nuclear transfer (NT), the fusion of a donor cell with an enucleated oocyte, can transmit both donor cell and… Expand
Epigenetic reprogramming in the porcine germ line
- S. M. Hyldig, Nicola Croxall, David A. Contreras, P. Thomsen, R. Alberio
- BMC Developmental Biology
- 25 February 2011
Epigenetic reprogramming is critical for genome regulation during germ line development. Genome-wide demethylation in mouse primordial germ cells (PGC) is a unique reprogramming event essential for… Expand
Reprogramming somatic cells into stem cells.
Recent scientific achievements in cell and developmental biology have provided unprecedented opportunities for advances in biomedical research. The demonstration that fully differentiated cells can… Expand
Modulation of Pluripotency in the Porcine Embryo and iPS Cells
The establishment of the pluripotent ICM during early mammalian development is characterized by the differential expression of the transcription factors NANOG and GATA4/6, indicative of the epiblast… Expand
Differential staining combined with TUNEL labelling to detect apoptosis in preimplantation bovine embryos.
- A. Fouladi-Nashta, R. Alberio, M. Kafi, B. Nicholas, K. H. Campbell, R. Webb
- Biology, Medicine
- Reproductive biomedicine online
Development of accurate laboratory methods to assess embryo quality will improve the efficiency of embryo production from in-vitro culture systems. Currently, the techniques of TdT (terminal… Expand
Differential acetylation of histone H4 lysine during development of in vitro fertilized, cloned and parthenogenetically activated bovine embryos
The oocyte is remarkable in its ability to remodel parental genomes following fertilization and to reprogram somatic nuclei after nuclear transfer (NT). To characterise the patterns of histone H4… Expand