Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety.
- K. Donaldson, R. Aitken, +4 authors A. Alexander
- Chemistry, Medicine
- Toxicological sciences : an official journal of…
- 1 July 2006
Carbon nanotubes (CNT) are an important new class of technological materials that have numerous novel and useful properties. The forecast increase in manufacture makes it likely that increasing human… Expand
Generation of reactive oxygen species, lipid peroxidation, and human sperm function.
Recent studies have demonstrated that human spermatozoa are capable of generating reactive oxygen species and that this activity is significantly accelerated in cases of defective sperm function. In… Expand
Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa.
Addition of the divalent cation ionophore, A23187, to washed populations of human spermatozoa resulted in a sudden burst of production of reactive oxygen species which peaked within 3-5 min. This… Expand
Applications and implications of nanotechnologies for the food sector
- Q. Chaudhry, M. Scotter, +5 authors R. Watkins
- Business, Medicine
- Food additives & contaminants. Part A, Chemistry…
- 1 March 2008
A review of current and projected nanotechnology-derived food ingredients, food additives and food contact materials is presented in relation to potential implications for consumer safety and… Expand
Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa.
- R. Aitken, E. Gordon, +4 authors D. S. Irvine
- Biology, Medicine
- Biology of reproduction
- 1 November 1998
Reactive oxygen metabolites are known to disrupt sperm-oocyte fusion, sperm movement, and DNA integrity; however, the relative sensitivities of these elements to oxidative stress are unknown. In this… Expand
Free radicals, lipid peroxidation and sperm function.
- R. Aitken
- Biology, Medicine
- Reproduction, fertility, and development
The cellular generation of reactive oxygen species was first observed in mammalian spermatozoa in the late 1940s. The field then remained dormant for 30 years until Thaddeus Mann and Roy Jones… Expand
Polyunsaturated Fatty Acids in Male and Female Reproduction1
Abstract In Westernized societies, average consumption of n-6 polyunsaturated fatty acids (PUFAs) far exceeds nutritional requirements. The ratio of n-6 to n-3 PUFAs is generally >10:1 whereas on a… Expand
Antioxidant systems and oxidative stress in the testes
Spermatogenesis is an extremely active replicative process capable of generating approxi mately 1,000 sperm a second. The high rates of cell division inherent in this process imply correspondingly… Expand
Mobile Phone Radiation Induces Reactive Oxygen Species Production and DNA Damage in Human Spermatozoa In Vitro
Background In recent times there has been some controversy over the impact of electromagnetic radiation on human health. The significance of mobile phone radiation on male reproduction is a key… Expand
DNA integrity in human spermatozoa: relationships with semen quality.
- D. S. Irvine, J. Twigg, E. Gordon, N. Fulton, P. Milne, R. Aitken
- Medicine, Biology
- Journal of andrology
- 2 January 2000
The literature contains conflicting evidence regarding the existence of DNA damage in spermatozoa from infertile male patients. To examine this phenomenon, we have studied ejaculated spermatozoa from… Expand