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High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.
Recently, the human ATP-binding cassette transporter-1 (ABC1) gene has been demonstrated to be mutated in patients with Tangier disease. To investigate the role of the ABC1 protein in an experimentalExpand
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Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages
The ATP-binding cassette transporter A1 (ABCA1) encodes a membrane protein that promotes cholesterol and phospholipid efflux from cells. Mutations in ABCA1 lead to HDL deficiency and tissueExpand
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Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice.
We have studied the effects of endogenous and exogenous estrogen on atherosclerotic lesions in apolipoprotein E-deficient mice. Female mice ovariectomized (OVX) at weaning displayed increases (P <Expand
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Reproductive and metabolic characteristics of dairy cattle supplemented with beta-carotene.
Seventy-eight Holstein cows alternately were assigned at calving to receive beta-carotene supplementation or act as controls to determine effects of beta-carotene on reproduction and carotene,Expand
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Triglyceride accumulation and very low density lipoprotein secretion by rat and goat hepatocytes in vitro.
Utilization of [1-14C] oleate by freshly isolated rat and goat hepatocytes was compared. Intracellular [14C] triglyceride accumulation by hepatocytes did not differ between species. At 2 h ofExpand
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Leukotriene B4 Receptor Antagonism Reduces Monocytic Foam Cells in Mice
Leukotriene B4 (LTB4) is a potent chemotactic agent that activates monocytes through the LTB4 receptor (BLTR). We tested the hypothesis that LTB4 receptor blockade would slow atheroscleroticExpand
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Effects of dietary calcium and age on parathyroid hormone, calcitonin and serum and milk minerals in the periparturient dairy cow.
Ten pregnant heifers and 10 pregnant cows (three or more pregnancies) were assigned to groups of five and fed either the recommended (low) amount of calcium or excess (high) calcium in their diet forExpand
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Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice.
The pro-inflammatory chemokine, monocyte chemoattractant protein-1 (MCP-1), plays a fundamental role in monocyte recruitment and has been implicated as a contributing factor to atherosclerosis. TheExpand
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Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels.
Excess accumulation of cholesterol in macrophages results in foam cell production and lesion development. Recent studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) is highlyExpand
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Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes
Glucokinase is a key regulator of glucose homeostasis, and small molecule allosteric activators of this enzyme represent a promising opportunity for the treatment of type 2 diabetes. SystemicallyExpand
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