R. Aft

Publications188
h-index45
Citations8,184
Highly Influential Citations260
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Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft
TLDR
The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within thePrimary tumour.
Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.
Correlates of fear of cancer recurrence in women with ductal carcinoma in situ and early invasive breast cancer
TLDR
Management of anxiety, provision of social support, and patient education may help reduce FCR among DCIS and EIBC survivors, especially among younger survivors.
Breast Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.
TLDR
The NCCN Guidelines specific to the workup and treatment of patients with recurrent/stage IV breast cancer are discussed in this article.
Therapeutic management of intracystic papillary carcinoma of the breast: the roles of radiation and endocrine therapy.
Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death
TLDR
It is concluded that 2-deoxy-D-glucose treatment causes death in human breast cancer cell lines by the activation of the apoptotic pathway, and the targeting of glucose metabolism as a site for chemotherapeutic intervention by agents such as 2- deoxy- D- glucose is supported.
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
TLDR
It is demonstrated that p53 is a major determinant of how TNBCs respond to therapies that combine DNA damage with Chk1 inhibition, either as single agents or in combination.
Metastatic disease to the breast: the Washington University experience
TLDR
Due to the variable course of patients with metastatic disease, a multi-disciplinary approach is necessary for each patient with disease metastatic to the breast to determine optimal treatment.
Hemin-mediated DNA strand scission.
Effects of breast cancer surgery and surgical side effects on body image over time
TLDR
The impact of surgery type on body image within the first year of definitive surgical treatment was explained by surgical side-effects severity, and after 2 years, body image problems did not differ significantly by surgery type.
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