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NF-kappaB functions as a tumour promoter in inflammation-associated cancer.
The causes of sporadic human cancer are seldom recognized, but it is estimated that carcinogen exposure and chronic inflammation are two important underlying conditions for tumour development, theExpand
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Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
As a result of deprivation of oxygen (hypoxia) and nutrients, the growth and viability of cells is reduced. Hypoxia-inducible factor(HIF)-1α helps to restore oxygen homeostasis by inducingExpand
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NF-κB functions as a tumour promoter in inflammation-associated cancer
The causes of sporadic human cancer are seldom recognized, but it is estimated that carcinogen exposure and chronic inflammation are two important underlying conditions for tumour development, theExpand
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VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells
Adult neovascularization relies on the recruitment of circulating cells, but their angiogenic roles and recruitment mechanisms are unclear. We show that the endothelial growth factor VEGF isExpand
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Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
Hormone refractory metastatic prostate cancer remains an incurable disease. We found that high expression levels of the chemokine receptor CXCR4 correlated with the presence of metastatic disease inExpand
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Conditional switching of VEGF provides new insights into adult neovascularization and pro‐angiogenic therapy
To gain insight into neovascularization of adult organs and to uncover inherent obstacles in vascular endothelial growth factor (VEGF)‐based therapeutic angiogenesis, a transgenic system forExpand
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correction: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
This corrects the article DOI: 10.1038/28867
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Mutant KRAS is a druggable target for pancreatic cancer
Significance Pancreatic cancer is still one of the major challenges in clinical oncology. Mutant KRAS is a driving oncogene in the majority of human pancreatic cancer cases. We have made an effort toExpand
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