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Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred.
TLDR
Somatic mutations of hMSH6 were observed in three colorectal tumors from the patient, indicating two-hit inactivation, and microsatellite instabilities at mononucleotide repeats were detected in all three tumors, suggesting that h MSH6 is responsible for tumorigenesis in atypical HNPCC.
Tamoxifen-induced apoptosis in breast cancer cells relates to down-regulation of bcl-2, but not bax and bcl-X(L), without alteration of p53 protein levels.
TLDR
It is demonstrated that TAM can induce apoptosis in a time- and dose-dependent manner by modulating b cl-2 levels in breast cancer cells, and down-regulation of bcl-2 induced by TAM was not accompanied by alterations in p53 levels.
A case-control study of breast cancer among Japanese women: with special reference to family history and reproductive and dietary factors
TLDR
Obesity, single marital status, fewer births, a late childbirth, and less consumption of green-yellow vegetables and dairy products were associated with an increased risk of breast cancer in patients with breast cancer and matched controls in Japan.
Subungual melanoma. A clinicopathologic study of 16 Japanese cases
TLDR
No statistically significant differences in rate were found between subungual melanoma and volar melanoma, and the term “acral” melanoma is recommended to describe the melanomas in the acral regions, because it is descriptive of the regions directly affected.
Intraductal extension of primary invasive breast carcinoma treated by breast conservative surgery. Computer graphic three‐dimensional reconstruction of the mammary duct‐lobular systems
TLDR
This work has shown that intraductal tumor extension within the mammary ductal tree is a characteristic feature of primary breast carcinoma, and is an important consideration in patients undergoing breast conservative surgery.
Apoptotic index correlates to bcl-2 and p53 protein expression, histological grade and prognosis in invasive breast cancers.
TLDR
The results indicate that low AI is related to a number of clinicopathologic and biologic parameters known to predict a lower risk of recurrence and is associated with a favourable survival in invasive breast cancers, but it was not an independent prognostic factor for clinical outcome in this patient series.
Postoperative adjuvant therapy with tamoxifen, tegafur plus uracil, or both in women with node-negative breast cancer: a pooled analysis of six randomized controlled trials.
TLDR
Adjuvant UFT improves the overall survival of node-negative breast cancer patients and is suggested that UFT can be a useful alternative to doxorubicin and cyclophosphamide, or cycloph phosphamide, methotrexate, and fluorouracil in the adjuvant treatment for node- negative breast cancer.
Mass Screening for Breast Cancer: Comparison of the Clinical Stages and Prognosis of Breast Cancer Detected by Mass Screening and in Out‐patient Clinics
TLDR
Women who had conducted breast self‐examination (BSE) showed a higher survival rate than those who had not conducted BSE, and patients detected by mass screening in 11 regions of Japan showed a significantly higher 5‐year and 10‐year survival rate.
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