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Enteric neuropathy evoked by repeated cisplatin in the rat
Background  Acute administration of the antitumoral drug cisplatin can induce nausea/emesis and diarrhea. The long‐term effects of cisplatin on gastrointestinal motility, particularly after repeatedExpand
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Food, nutrients and nutraceuticals affecting the course of inflammatory bowel disease.
Inflammatory bowel diseases (ulcerative colitis; Crohn's disease) are debilitating relapsing inflammatory disorders affecting the gastrointestinal tract, with deleterious effect on quality of life,Expand
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Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments
Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and Diarrhea (CID) present aExpand
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Radiological study of gastrointestinal motor activity after acute cisplatin in the rat. Temporal relationship with pica
Nausea and vomiting are amongst the most severe dose-limiting side effects of chemotherapy. Emetogenic activity in rats can only be evaluated by indirect markers, such as pica (kaolin intake), orExpand
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Cannabinoid/agonist WIN 55,212‐2 reduces cardiac ischaemia–reperfusion injury in Zucker diabetic fatty rats: role of CB2 receptors and iNOS/eNOS
Diabetes increases cardiac damage after myocardial ischaemia. Cannabinoids can protect against myocardial ischaemia/reperfusion injury. The aim of this study was to examine the cardioprotectiveExpand
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Ileal myenteric plexus in aged guinea‐pigs: loss of structure and calretinin‐immunoreactive neurones
Abstract  Myenteric plexus controls gastrointestinal motility by means of well organized circuits which are comprised of sensory neurones, interneurones and motor neurones to the muscular layers.Expand
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The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212‐2 on gastrointestinal motility in the rat
Background  In the absence of pathology, cannabinoid‐induced depression of gastrointestinal (GI) motility is thought to be mediated primarily by CB1 receptors, whereas the role of CB2 receptors isExpand
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Characterization of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy
Clinical use of antineoplastic drugs is associated with the development of numerous adverse effects that many patients find intolerable, including peripheral neuropathy. Cannabinoids have relievedExpand
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Cannabinoids may worsen gastric dysmotility induced by chronic cisplatin in the rat
Background  Although cannabinoids have traditionally been used for the treatment and/or prevention of nausea and/or emesis, anorexia and weight loss induced by clinical use of antineoplastic drugs,Expand
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Cannabinoid pharmacology and therapy in gut disorders
Graphical abstract Figure. No Caption available. ABSTRACT Cannabis sp. and their products (marijuana, hashish…), in addition to their recreational, industrial and other uses, have a long history forExpand
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