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Asymmetric catalysis of aldol reactions with chiral lewis bases.
In an extension of studies both on the stereochemical course of the aldol addition and on Lewis-base-catalyzed allylation reactions, we have invented a new Lewis-base-catalyzed asymmetric aldolExpand
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Cyclopropanation with Diazomethane and Bis(oxazoline)palladium(II) Complexes.
Studies toward the development of an enantioselective diazomethane-based cyclopropanation reagent derived from bis(oxazoline)palladium(II) complexes are reported. Several simple palladium chelates, 2Expand
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The Chemistry of Trichlorosilyl Enolates. Aldol Addition Reactions of Methyl Ketones
Investigations on the aldol addition chemistry of trichlorosilyl enolates derived from methyl ketones are presented in full. These trichlorosilyl enolates are competent aldol reagents in the absenceExpand
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The Chemistry of Trichlorosilyl Enolates. 2. Highly-Selective Asymmetric Aldol Additions of Ketone Enolates
Despite consider-able success to date, these efforts have identified the samesolution to the problem, namely, the invention/discovery of asuitable chiral Lewis acid catalyst to effect the reactionExpand
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Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General
Small molecules have been used to explore many facets of biology for over a century. However, research in biology is not routinely performed using this approach, in the way that it is withExpand
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Chiral Phosphoramide-Catalyzed Aldol Additions of Ketone Enolates. Preparative Aspects
Trichlorosilyl enolates of ketones (enoxytrichlorosilanes) were demonstrated to be highly reactive aldol addition reagents. Trichlorosilyl enolates of cyclohexanone (E-enolate) and propiophenoneExpand
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Chiral phosphoramide-catalyzed aldol additions of ketone trichlorosilyl enolates. Mechanistic aspects.
The mechanism of the catalytic, enantioselective addition of trichlorosilyl enolates to aldehydes has been investigated. Kinetic studies using ReactIR and rapid injection NMR (RINMR) spectroscopyExpand
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Chapter 6 - Rho-Kinase Inhibitors for Cardiovascular Disease
Publisher Summary Rho kinases (also known as Rho-associated kinases, Rho-associated coiled-coil forming protein kinases, ROCK) are two highly similar (92% homology in their catalytic domains, 65%Expand
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