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Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice.
TLDR
Greater than 85% of the total radioactivity excreted in urine, bile, and feces from all three mouse strains was present as metabolites of TCDD. Expand
Toxicology of thiono-sulfur compounds.
Thiono-sulfur-containing compounds cause a wide variety of toxic effects in mammals. These toxic effects of thiono-sulfur-containing compounds appear to be at least partially the result of theirExpand
Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system.
TLDR
The data suggest that both thioacetamide and thio acetamide sulfine are activated by hepatic mixed-function oxidase enzymes to a hepatotoxic compound(s), and suggest that the hepatotoxicity may be mediated by its metabolism to thioestate sulfine which, in turn, is metabolized to an ultimate toxic metabolite. Expand
The examination and quantitation of tissue cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using hydroxylapatite.
TLDR
Data support the hypothesis that, as in mice, the particular cytosol binding species in rats is the receptor that may mediate the induction of aryl hydrocarbon hydroxylase activity. Expand
Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster.
TLDR
The hamster appears to be the least sensitive mammalian species to the lethal effect of TCDD that has yet been investigated. Expand
Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.
TLDR
The apparent absence of TCDD metabolites in extracts of liver or adipose tissue indicates that the biotransformed products of T CDD are readily excreted in urine and bile. Expand
STUDIES OF THE MECHANISMS OF TOXICITY OF 2,3,7,8‐TETRACHLORODIBENZO‐p‐DIOXIN (TCDD)
TLDR
The major interest of the laboratory relative to TCDD has been the biochemical mechanism or mechanisms of acute lethality of this compound and the data that have been forthcoming from the various studies, in conjunction with data from future experiments, may eventually allow investigators in this field to postulate a mechanism for the acute lethal effects of T CDD. Expand
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