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Identification of candidate epigenetic biomarkers for ovarian cancer detection.
The data have identified, for the first time, GTF 2A1 alone, or GTF2A1 plus HAAO are excellent candidate biomarkers for detecting this disease. Expand
Prognostic impact of MAD1L1 promoter hypermethylation in advanced ovarian cancer.
- R. A. Jansen, J. Liu, +7 authors R. Brown
- Journal of clinical oncology : official journal…
- 20 June 2006
Induced overexpression of MAD1L1 has been shown to delay cell proliferation and inhibit growth, and is a potential target for intervention therapies that could improve patient survival. Expand
Dysregulation of TGFβ/Smad4 signaling and contribution of a CpG island methylator phenotype in ovarian cancer
This study combined both chromatin immunoprecipitation microarray (ChIP-chip) and differential methylation hybridization (DMH) to investigate this epigenetic mechanism in ovarian cancer and found patients with high degrees of concurrent hypermethylation had significantly shorter progression-free survival. Expand