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Vaccine-Induced Antibodies Inhibit CETP Activity In Vivo and Reduce Aortic Lesions in a Rabbit Model of Atherosclerosis
- C. Rittershaus, D. Miller, +10 authors U. Ryan
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 September 2000
Using a vaccine approach, we immunized New Zealand White rabbits with a peptide containing a region of cholesteryl ester transfer protein (CETP) known to be required for neutral lipid transfer… Expand
The partly folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands.
- P. B. Furtado, C. Y. Huang, Demvihin Ihyembe, R. A. Hammond, H. Marsh, S. Perkins
- Chemistry, Medicine
- Journal of molecular biology
- 4 January 2008
Human complement receptor type 1 (CR1, CD35) is a type I membrane-bound glycoprotein that belongs to the regulators of complement activity (RCA) family. The extra-cellular component of CR1 is… Expand
Identification of DNA polymerase delta in CV-1 cells: studies implicating both DNA polymerase delta and DNA polymerase alpha in DNA replication.
DNA polymerases delta and alpha were purified from CV-1 cells, and their sensitivities to the inhibitors aphidicolin, (p-n-butylphenyl)deoxyguanosine triphosphate (BuPdGTP), and monoclonal antibodies… Expand
Co-administration of a CpG adjuvant (VaxImmuneTM, CPG 7909) with CETP vaccines increased immunogenicity in rabbits and mice
Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of neutral lipids and phospholipids between lipoproteins and contributes to the regulation of the… Expand
Endotoxin induction of nitric oxide synthase and cyclooxygenase-2 in equine alveolar macrophages.
- R. A. Hammond, R. Hannon, S. Frean, S. J. Armstrong, R. Flower, C. Bryant
- Biology, Medicine
- American journal of veterinary research
- 1 April 1999
OBJECTIVE To determine the amount of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) enzymes induced in vitro in equine alveolar macrophages in response to lipopolysaccharide… Expand
Effect of DNA polymerase inhibitors on DNA repair in intact and permeable human fibroblasts: evidence that DNA polymerases delta and beta are involved in DNA repair synthesis induced by…
The involvement of DNA polymerases alpha, beta, and delta in DNA repair synthesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in human fibroblasts (HF). The effects of… Expand
The partly-folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) indicates inter-SCR flexibility
A microinjected monoclonal antibody against human DNA polymerase-alpha inhibits DNA replication in human, hamster, and mouse cell lines.
- L. Kaczmarek, M. Miller, R. A. Hammond, W. Mercer
- Medicine, Biology
- The Journal of biological chemistry
- 15 August 1986
We have examined the effect that microinjection of a monoclonal antibody directed against human DNA polymerase-alpha (SJK-287) has on DNA synthesis in exponentially growing human, mouse, and hamster… Expand
Calcium-dependent calmodulin-binding proteins associated with mammalian DNA polymerases α
Abstract Complex, multiprotein forms of bovine (calf thymus), hamster (Chinese hamster ovary cell), and human (HeLa) cell DNA polymerase α (Polα) were analyzed for their content of calmodulin-binding… Expand
Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology.
- L. Thomas, K. Panneerselvam, +9 authors Robert J. Bayer
- Medicine, Chemistry
- 1 October 2004
Recombinant soluble human complement receptor type 1 (sCR1) is a highly glycosylated glycoprotein intended for use as a drug to treat ischemia-reperfusion injury and other complement-mediated… Expand