• Publications
  • Influence
Separate Populations of Receptor Cells and Presynaptic Cells in Mouse Taste Buds
TLDR
Functional calcium imaging and single-cell reverse transcription (RT)-PCR demonstrate the existence of at least two molecularly distinct functional classes of taste cells: receptor cells and synapse-forming cells. Expand
Potassium-Coupled Chloride Cotransport Controls Intracellular Chloride in Rat Neocortical Pyramidal Neurons
TLDR
Thermodynamic considerations predict that in the physiological ranges of intracellular Cl− and extracellular K+ concentrations, KCC2 can act to either extrude or accumulate Cl−, and data demonstrate a physiologically relevant and developmentally regulated role for K CC2 in Cl− homeostasis via both Cl− extrusion and accumulation. Expand
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway
TLDR
In vivo resveratrol pretreatment confers neuroprotection similar to IPC via the SIRT1-UCP2 pathway, and significantly increased the ADP/O ratio in hippocampal mitochondria reflecting enhanced ATP synthesis efficiency. Expand
Activation of A-type gamma-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons.
TLDR
In green fluorescent protein-identified adult mouse GnRH neurons in brain slices, gramicidin-perforated-patch-clamp experiments revealed the reversal potential (E(GABA))) for current through GABA(A)Rs was depolarized relative to the resting potential, suggesting the physiological consequence of synaptic activation of GABA (A)R in Gn RH neurons is excitation. Expand
Activation of A-Type γ-Aminobutyric Acid Receptors Excites Gonadotropin-Releasing Hormone Neurons
TLDR
In green fluorescent protein-identified adult mouse GnRH neurons in brain slices, gramicidin-perforated-patch-clamp experiments revealed the reversal potential (E(GABA))) for current through GABA(A)Rs was depolarized relative to the resting potential, suggesting the physiological consequence of synaptic activation of GABA (A)R in Gn RH neurons is excitation. Expand
Metabolic Regulation of Fertility through Presynaptic and Postsynaptic Signaling to Gonadotropin-Releasing Hormone Neurons
TLDR
It is demonstrated that fasting and leptin act presynaptically and postsynaptically to alter GABAergic drive to GnRH neurons, providing evidence for GABAergic communication of metabolic cues to Gn RH neurons, and suggest the possibility for functional leptin receptors on GnRH neuron. Expand
Mechanisms underlying episodic gonadotropin-releasing hormone secretion
TLDR
Three primary aspects of this intermittent hormonal signal are explored: the source of rhythm, the possible mechanisms comprising oscillator(s), and how GnRH neurons are synchronized to produce a pulse of hormone release into the pituitary portal blood. Expand
Estradiol feedback alters potassium currents and firing properties of gonadotropin-releasing hormone neurons.
TLDR
Potassium channels are one target for estradiol regulation of GnRH neurons; this regulation involves changes in phosphorylation of potassium channel components, demonstrating a degree of specificity in these effects. Expand
Ischemic Preconditioning Targets the Respiration of Synaptic Mitochondria via Protein Kinase Cε
TLDR
It is proposed that, at 48 h of reperfusion after ischemic preconditioning, εPKC is poised at synaptic mitochondria to respond to ischemia either by direct phosphorylation or activation of the ε PKC signaling pathway. Expand
ɛPKC phosphorylates the mitochondrial K+ ATP channel during induction of ischemic preconditioning in the rat hippocampus
TLDR
The hypothesis that the brain mtK(+)(ATP) channel is an important target of IPC and the signal transduction pathways initiated by epsilonPKC is supported. Expand
...
1
2
3
4
5
...