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Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex
A novel lipid‐anchored A‐kinase Anchoring Protein facilitates cAMP‐responsive membrane events
Cloned a low‐molecular weight A‐kinase Anchoring Protein, called AKAP18, is cloned, which targets the cAMP‐dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L‐type calcium channel, and facilitates GLP‐1‐mediated insulin secretion in a pancreatic β cell line.
The effects of hormone replacement therapy and raloxifene on C-reactive protein and homocysteine in healthy postmenopausal women: a randomized, controlled trial.
HRT and raloxifene lower serum homocysteine levels to a comparable extent in postmenopausal women, and the relationship between elevated C-reactive protein levels with HRT and cardiovascular disease events requires further study.
PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum.
- D. Little, R. A. Dean, A. Blikslager
- Biology, MedicineAmerican journal of physiology. Gastrointestinal…
These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution.
Role of tumor necrosis factor-alpha and interleukin-6 in the effects of hormone replacement therapy and raloxifene on C-reactive protein in postmenopausal women.
Umbilical cord thiocyanate and thyroid function in intrauterine growth-restricted infants of the smoking gravida.
- M. McMahon, H. Brown, R. A. Dean
- MedicineJournal of perinatology : official journal of the…
- 1 September 1997
Thiocyanate was not more concentrated in the intrauterine growth-restricted infant and did not correlate with thyroid function or birth weight, and the thyroxine level was decreased significantly in intrauterin growth- restricted infants born to nonsmoking mothers.
Transient porphyrinemia in a liver transplant recipient.
- A. L. Blemker, R. A. Dean, D. C. Weaver, M. Pescovitz, R. Filo, P. Treadwell
- MedicineArchives of dermatology
- 1 May 1991
Fractionation showed that the levels of the hydrophobic porphyrins, coproporphyr in and protoporphyrin, were elevated, while the Levels of the Hydrophilic porphyrs remained normal following the successful second liver transplantation.
Cytologic diagnosis of liver fluke infestation in a patient with subsequently documented cholangiocarcinoma.
In a 32-year-old Laotian immigrant who presented with a two-day history of vomiting, abdominal pain and jaundice, ultrasound examination revealed a posthepatic obstruction and a coexistent cholangiocarcinoma.
mucosal recovery in ischemia-injured porcine ileum PI3K signaling is required for prostaglandin-induced
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