• Publications
  • Influence
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Introduction Trained immunity refers to the memory characteristics of the innate immune system. Memory traits of innate immunity have been reported in plants and invertebrates, as well as in miceExpand
  • 738
  • 37
A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus
At the site of microbial infections, the significant influx of immune effector cells and the necrosis of tissue by the invading pathogen generate hypoxic microenvironments in which both the pathogenExpand
  • 233
  • 20
Transcriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
Secondary metabolites, including toxins and melanins, have been implicated as virulence attributes in invasive aspergillosis. Although not definitively proved, this supposition is supported by theExpand
  • 289
  • 19
Disruption of a Nonribosomal Peptide Synthetase in Aspergillus fumigatus Eliminates Gliotoxin Production
ABSTRACT The fungal secondary metabolite gliotoxin produced by Aspergillus fumigatus has been hypothesized to be important in the development of invasive aspergillosis. In this study, we addressedExpand
  • 180
  • 16
Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
The number of immunocompromised patients with invasive fungal infections continues to increase and new antifungal therapies are not keeping pace with the growing incidence of these infections andExpand
  • 265
  • 12
Iridovirus and Microsporidian Linked to Honey Bee Colony Decline
Background In 2010 Colony Collapse Disorder (CCD), again devastated honey bee colonies in the USA, indicating that the problem is neither diminishing nor has it been resolved. Many CCDExpand
  • 194
  • 12
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus
Sterol regulatory element binding proteins (SREBPs) are a class of basic helix-loop-helix transcription factors that regulate diverse cellular responses in eukaryotes. Adding to the recognizedExpand
  • 127
  • 9
Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus
ABSTRACT The calcineurin pathway is a critical signal transduction pathway in fungi that mediates growth, morphology, stress responses, and pathogenicity. The importance of the calcineurin pathway inExpand
  • 120
  • 9
Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans
Carbon catabolite repression (CCR) is a process that selects the energetically most favorable carbon source in an environment. CCR represses the use of less favorable carbon sources when a betterExpand
  • 66
  • 9
Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus.
Fungi from the genus Aspergillus are important saprophytes and opportunistic human fungal pathogens that contribute in these and other diverse ways to human well-being. Part of their impact on humanExpand
  • 60
  • 8