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Cholinolytics in the treatment of anticholinesterase poisoning. V. The effectiveness of Parpanit with oximes in the treatment of organophosphorus poisoning.
- I. Coleman, G. Patton, R. A. Bannard
- Chemistry, Medicine
- Canadian journal of physiology and pharmacology
The effectiveness of Parpanit in the treatment of organophosphorus poisoning was examined and compared with that of atropine sulfate. The potency of Parpanit was assessed in the mouse, rat, hamster,… Expand
GUANIDINE COMPOUNDS. II. PREPARATION OF MONO- AND N,N-DI-ALKYLGUANIDINES
1-Guanyl-3,5-dimethylpyrazole nitrate is superior to S-methylisothiouronium sulphate as a reagent for preparation of simple salts of mono- and N,N-di-alkylguanidines from cyclohexylamine,… Expand
Cholinolytics in the treatment of anticholinesterase poisoning. II. Treatment of sarin poisoning with an oxime and various combinations of cholinolytic compounds.
- I. Coleman, P. Little, R. A. Bannard
- Chemistry, Medicine
- Canadian journal of biochemistry and physiology
- 1 June 1962
Thirty-four cholinolytic compounds were screened for protective activity in mice and rats exposed to sarin. All compounds were examined at a dosage of 50 μmoles/kg in the presence of 30 mg/kg of N-...
PREPARATION OF ANTIDOTES FOR ANTICHOLINESTERASE POISONING: II. TERTIARY AND QUATERNARY SALTS OF PARPANIT AND PARPANIT ANALOGUES
PREPARATION OF ANTIDOTES FOR ANTICHOLINESTERASE POISONING III. ESTERS OF 1-ARYLCYCLOALKANECARBOXYLIC ACIDS
In preceding papers of this series (1, 2) the preparation of several analogues of 5'diethylaminoethyl 1-phenylcyclopentanecarboxylate hydrochloride (Parpanit) and certain of their quaternary salts… Expand
CYCLOHEXANE COMPOUNDS: V. THE REACTION OF 1-METHOXYCYCLOHEXENE-2 WITH AQUEOUS N-BROMOSUCCINIMIDE. THE 1-METHOXY-2-BROMO-3-HYDROXYCYCLOHEXANES
Abstract : Interaction of 1-methoxycyclohexene-2 and aqueous Nbromosuccinimide gave a mixture of stereoisomeric bromohydrins, which, on treatment with aqueous sodium hydroxide, furnished… Expand
CYCLOHEXANE COMPOUNDS: II. SYNTHESIS AND STRUCTURE OF TWO STEREOISOMERIC 3-AMINO-1,2-CYCLOHEXANEDIOLS
The stereoisomeric 1-ethoxy-2,3-epoxycyclohexanes were prepared from 1-ethoxycyclohexene-2 via 1-ethoxycyclohexene-2 bromohydrin. Ammonolysis of the lower- and higher-boiling oxides furnished 1α-et...
CYCLOHEXANE COMPOUNDS: III. THE 1-METHOXY- AND 1-ETHOXY-2-HYDROXY-3-BROMOCYCLOHEXANES
1α-Methoxy- 2β - hydroxy- 3α-bromocyclohexane and 1α-methoxy-2α-hydroxy-3β-bromocyclohexane have been prepared by the action of hydrobromic acid on 1β-methoxy-2α,3α-epoxycyclohexane and… Expand
N,N-DIACETYLAMINES AS BY-PRODUCTS FROM THE ACETYLATION OF AMINES
- R. A. Bannard
- 1 April 1964
Acetylation of five alicyclic amines and isopropylamine with a large excess of acetic anhydride for 1 hour under reflux led to formation of appreciable yields (23–35%) of N,N-diacetylamines in… Expand
Chromatographic separation of the 1-alkoxy-2(3)-hydroxy-3(2)-aminocyclohexanes and their derivatives.