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Cyclodextrins and Their Complexes - Structure and Interactions
Cyclodextrins (CD) are currently employed in analytical and preparative separations of enantiomers of chiral compounds as well as in some areas of organic and biological chemistry, biochemistry and…
Ferrocene phosphane-heteroatom/carbon bidentate ligands in asymmetric catalysis.
Hetero-bidentate phosphane ligands are hybrid ligands, which combine the properties of phosphorus with those of other donor atoms that create further asymmetry around the metal centre, which may be helpful for increasing the stereoinduction.
Asymmetric Mannich reaction catalyzed by N-arylsulfonyl-l-proline amides
The proteolytic stability of 'designed' beta-peptides containing alpha-peptide-bond mimics and of mixed alpha,beta-peptides: application to the construction of MHC-binding peptides.
- D. Hook, P. Bindschaedler, Y. Mahajan, R. Šebesta, P. Kast, D. Seebach
- Biology, ChemistryChemistry & biodiversity
Peptides comprised of alpha- and beta-amino acids (mixed alpha,beta-peptides, 8-11) are expected to benefit from both recognition by a natural receptor and a high level of proteolytic stability, ideal characteristics of pharmacologically active compounds.
Assessment of non-standard reaction conditions for asymmetric 1,3-dipolar organocatalytic cycloaddition of nitrone with α,β-unsaturated aldehydes
Non-standard experimental conditions can often enhance organocatalytic reactions considerably. The current study explores the effectiveness of a range of non-standard reaction conditions for the…
Catalysts with ionic tag and their use in ionic liquids
The concept of homogeneous supported catalysts has emerged as a useful alternative to homogeneous as well as heterogeneous catalysis, possibly combining positive aspects of both. Designing catalysts…
Copper-catalyzed enantioselective conjugate addition of organometallic reagents to acyclic dienones
The enantioselective, copper/phosphoramidite-catalyzed 1,4-addition of dialkylzinc reagents to acyclic dienones is described and can be further functionalized by a second conjugate addition, or employed in an enolate trapping, ring-closing metathesis protocol.
Are Ionic Liquids Suitable Media for Organocatalytic Reactions
Recent developments in organocatalysis have shown that these reactions can be advantageously performed in nonclassical media, such as ionic liquids or water. Among many organocatalysts, proline and…
Enantioselective Cu‐Catalyzed Functionalizations of Unactivated Alkenes
In situ generated copper hydride ligated with chiral ligands is able to catalyze enantioselective aminations of alkenes as well as intercepted by other electrophiles such as imines, organohalides, or boranes.
Asymmetric Transition-Metal Catalysis in the Formation and Functionalization of Metal Enolates
This review comprises two major parts, which have chiral metal enolates as their focus. In the first part, we discuss transition-metal-catalyzed conjugate additions leading to chiral enolates, which…