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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
TLDR
It is reported that HDACIs induce, in addition to p21, expression of TRAIL by directly activating the TNFSF10 promoter, thereby triggering tumor-selective death signaling in acute myeloid leukemia (AML) cells and the blasts of individuals with AML.
Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
TLDR
Nolz1 promotes RA signaling in the LGE, contributing to the striatal neurogenesis during development, and is shown to act downstream of Gsx2 to regulate RA-induced Neurogenesis.
Functions, therapeutic applications, and synthesis of retinoids and carotenoids.
Carotenoids Rosana Álvarez,† Beleń Vaz,† Hinrich Gronemeyer,‡ and Ángel R. de Lera*,† †Departamento de Química Orgańica, Centro de Investigacioń Biomed́ica (CINBIO), and Instituto de Investigacioń
Activation of Retinoic Acid Receptors by Dihydroretinoids
TLDR
It is proposed that both delivery of ligand to the nucleus and RAR activation favor retinoic acid over dihydroretinoids, and discrimination between the cognate ligand, retinic acid, and close analogs, occurs at multiple levels and may represent a mechanism to modulate retinoid-dependent physiological processes.
Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin
TLDR
It is suggested that dysregulated retinoid signaling in the skin mediated by RXR, RARα and/or RARγ may promote skin-based inflammation and dysregulation of skin barrier properties.
Increased adiposity in the retinol saturase‐knockout mouse
TLDR
Increased adiposity of RetSat‐null mice is associated with up‐regulation of PPARγ, a key transcriptional regulator of adipogenesis, and also its downstream target, fatty acid‐binding protein 4 (FABP4/aP2).
Production of hemicellulosic sugars from Pinus pinaster wood by sequential steps of aqueous extraction and acid hydrolysis
Pinus pinaster wood samples were subjected to aqueous extraction at 130°C to remove extractives and to a sequential stage of hydrothermal processing under selected operational conditions to obtain
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