R. Álvarez

Publications182
h-index34
Citations3,866
Highly Influential Citations56
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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
Chromatin is a dynamic macromolecular structure epigenetically modified to regulate specific gene expression. Altered chromatin function can lead to aberrant expression of growth regulators and may,… Expand
Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10
AKR1B10 is a human aldo-keto reductase (AKR) found to be elevated in several cancer types and in precancerous lesions. In vitro, AKR1B10 exhibits a much higher retinaldehyde reductase activity than… Expand
Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
BackgroundNolz1 is a zinc finger transcription factor whose expression is enriched in the lateral ganglionic eminence (LGE), although its function is still unknown.ResultsHere we analyze the role of… Expand
Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins.
In the retinal rod and cone photoreceptors, light photoactivates rhodopsin or cone visual pigments by converting 11-cis-retinal to all-trans-retinal, the process that ultimately results in… Expand
Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.
Only one of the three-retinoic acid receptors, RARbeta, is frequently deleted or epigenetically silenced at early stages in tumor progression and there is compelling evidence that RARbeta corresponds… Expand
Functions, therapeutic applications, and synthesis of retinoids and carotenoids.
Carotenoids Rosana Álvarez,† Beleń Vaz,† Hinrich Gronemeyer,‡ and Ángel R. de Lera*,† †Departamento de Química Orgańica, Centro de Investigacioń Biomed́ica (CINBIO), and Instituto de Investigacioń… Expand
Activation of Retinoic Acid Receptors by Dihydroretinoids
Vitamin A-derived metabolites act as ligands for nuclear receptors controlling the expression of a number of genes. Stereospecific saturation of the C13-C14 double bond of all-trans-retinol by the… Expand
Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels.
NADP(H)-dependent cytosolic aldo-keto reductases (AKRs) have been added to the group of enzymes which contribute to oxidoreductive conversions of retinoids. Recently, we found that two members from… Expand
Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.
Largazole 4a and analogues with modifications at the C7 position, as well as 2,4'-bithiazole 5a, have been synthesized using an acyclic cross-metathesis of the corresponding depsipeptide structures… Expand
Synthesis of Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities
A group of benzamides related to anacardic acid amide CTPB with alkyl chains of defined length were prepared by a five‐step sequence starting from 2,6‐dihydroxybenzoic acid, and their activities were… Expand
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