R. Z. Dautova

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Compounds (Ia-c), (IIa-e), and (III) were obtained by hydroxyalkylation of 1,3,3-trimethyl-3,4-dihydroisoquinolines with hexafluoroacetone or trifluoropyruvate esters, as reported in [6]. These compounds were obtained in a preparative form as their water-soluble hydrochlorides, prepared by passing HCI through a solution of the appropriate base in dry ether(More)
Isoquinoline alkaloids and their synthetic analogs are known to possess antiarrhythmic properties [i, 14], and to influence the process of blood clotting [6-& 13]. The relationships between the structures of these compounds and their antiarrhythmic or anticoagulant properties has hitherto received no attention. We are also unaware of any isoquinoline(More)
It has been reported [3, 4, 8] that compounds containing the isoquinoline ring show high antiaggregational activity with respect to thrombocytes, but the pharmacological activity of these compounds is low, being no greater than that of papaverine. It was therefore of interest to carry out a further search for novel isoquinolines in order to establish(More)
As is known, the class of 3,4-dihydroisoquinoline derivafives exhibits a broad spectrum of pharmacological activity [1 -4] , including compounds producing spasmolytic [5], antiarrhythmie and antiaggregative [6], and hypotensive effects [7]. Acid hydrazides and hydrazones of earbonyl compounds constitute another class of substances offering a broad spectrum(More)
As is known, isoquinoline derivatives possess antiarrhythmic and and anticoagulant properties [ 1 8]. Previously we have reported on these types of activity in 3,4-dihydroisoquinoline derivatives [9, 10]. The purpose of this work is to synthesize a series of oximes of 3,3-disubstituted 3,4-dihydroisoquinoline derivatives and study their antiarrhythmic and(More)
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