R Truscott

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Cataract is the major cause of blindness; the most common form is age-related, or senile, cataract. The reasons for the development of cataract are unknown. Here we demonstrate that nuclear cataract is associated with the extensive hydroxylation of protein-bound amino acid residues, which increases with the development of cataract by up to 15-fold in the(More)
w This work aims to test the hypothesis that age-related loss of the molecular chaperone activity of a-crystallin may be involved in the precipitation of lens proteins and subsequent cataract development. &&Q& acrystallins of dierent ages were isolated from concentric tissue layers removed from foetal and adull bovine lenses. They were examined for(More)
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