R. Thangarajan

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Human papillomavirus infection (HPV) and HPV related immune perturbation play important roles in the development of cervical cancer. Since mature dendritic cells (DCs) are potent antigen-presenting cells (APC), they could be primed by HPV antigens against cervical cancers. In this study we were able to generate, maintain and characterize, both(More)
Building a continuous speech recognizer for the Indian language like Tamil is a challenging task due to the unique inherent features of the language like long and short vowels, lack of aspirated stops, aspirated consonants and many instances of allophones. Stress and accent vary in spoken Tamil language from region to region. But in formal read Tamil(More)
We and others show that SOSTDC1 is down-regulated in breast cancer tissues compared to matched normal tissues. Previously, we found that epigenetic mechanisms underlie the down-regulation of SOSTDC1 in gastric cancer cells. The aim of this study was to assess the putative epigenetic regulation of SOSTDC1 expression in breast cancer cells. Microarray-based(More)
Environmental robustness is an important area of research in speech recognition. Mismatch between trained speech models and actual speech to be recognized is due to factors like background noise. It can cause severe degradation in the accuracy of recognizers which are based on commonly used features like mel-frequency cepstral co-efficient (MFCC) and linear(More)
OBJECTIVE To differentiate plasma from ovarian cancer and healthy individuals using MALDI-TOF mass spectroscopy. MATERIALS AND METHODS MALDI-TOF was used to generate profiles of immuno-depleted plasma samples (89 cancers and 199 healthy individuals) that were fractionated using three types of magnetic beads (HIC8, WCX and IMAC-Cu). RESULTS(More)
A Wireless Sensor Network (WSN) consists of several sensor nodes that are deployed in a aggressive environment to monitor and record the changes that take place in certain parameters of the environment. Sensor nodes that can communicate with each other over a wireless channel can be captured and compromised by an adversary. After such a compromise an(More)
Mitochondria are prominently understood as power houses producing ATP the primary energy currency of the cell. However, mitochondria are also known to play an important role in apoptosis and autophagy, and mitochondrial dysregulation can lead to pathological outcomes. Mitochondria are known to contain 1500 proteins of which only 13 are coded by(More)